Efficacy of antimicrobial agents incorporated in orthodontic bonding systems: a systematic review and meta-analysis

Almeida, Carianne Mendes de; Rosa, Wellington Luiz Oliveira da; Meereis, Carine Taís Welter; Almeida, Solange María de; Ribeiro, Juliana Silva; Silva, A. F. da; Lund, Rafael Guerra

doi:10.1080/14653125.2018.1443872

Cited by 27 publications

(20 citation statements)

References 42 publications

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“…The methodological quality of each included in vitro study was assessed by two reviewers according to the parameters of the previous systematic review 14,15 . The risk of bias of the article was evaluated according to the description given of the following parameters: random sequence generation, selective reporting, coefficient of variation, incomplete outcome data, blinding and other bias.…”

Section: Methodsmentioning

confidence: 99%

Bonding Strength of Universal Adhesives to Indirect Substrates: A Meta‐Analysis of in Vitro Studies

Cuevas‐Suárez

Rosa

Vitti

et al. 2020

Journal of Prosthodontics

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Purpose: To evaluate the in vitro bond strength of universal adhesive systems to indirect substrates. Material and Methods: Two reviewers performed a literature search up to March 2018 in seven databases: PubMed, Web of Science, SciELO, Scopus, LILACS, IBECS, and BBO. The review included studies that compared the bond strength of universal adhesives and well-established material-specific primers to indirect substrates: lithium disilicate ceramic, yttrium-stabilized zirconium dioxide ceramic, leucite-reinforced ceramic, feldspathic porcelain, polymer infiltrated ceramic material, resin composite or metal alloys. Analyses were carried out using RevMan 5.3.5. A global comparison was performed with the standardized mean difference using a random-effects models at a significance level of p < 0.05. Results: A total of 45 studies were included in the qualitative analysis, and the meta-analysis was performed with 42 studies. Bond strength to glass-based ceramics and alloys was improved with the use of a specific-primer as separate step before the bonding procedures (lithium disilicate, p < 0.001; alloys, p < 0.001). The bond strength to zirconium substrates was improved with the use of universal adhesives (p < 0.001). For bond strength to composite resin as indirect substrate, universal adhesives performed in a manner similar to that of the material-specific primer (p = 0.11). Conclusions:The clinical procedure of luting zirconia and resin composite restorations could be simplified by using single-bottle universal adhesives. However, the ability of universal adhesives to achieve an adequate and durable bond to glass-based ceramics and alloys appears to be limited.

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Section: Methodsmentioning

confidence: 99%

Bonding Strength of Universal Adhesives to Indirect Substrates: A Meta‐Analysis of in Vitro Studies

Cuevas‐Suárez

Rosa

Vitti

et al. 2020

Journal of Prosthodontics

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“…However, the multifactorial nature of the disease assumes that the increased or reduced presence of dental plaque does not translate per se into respective high or low level of WSL incidence . Unlike other studies, the purpose of our review was to evaluate the more clinically relevant outcome of WSL development which in fact has an impact on the final aesthetic outcome and on the integrity of dental structure. In addition, according to our protocol we intended to include also the aesthetic assessment of the teeth and WSL by laypersons or patients but without success due to no availability of data.…”

Section: Discussionmentioning

confidence: 99%

Prevention of orthodontic enamel demineralization: A systematic review with meta‐analyses

Tasios

Papageorgiou

Papadopoulos

et al. 2019

Orthod Craniofacial Res

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Aim of this systematic review was to assess the efficacy of preventive interventions against the development of white spot lesions (WSLs) during fixed appliance orthodontic treatment. Nine databases were searched without limitations in September 2018 for randomized trials. Study selection, data extraction and risk of bias assessment were done independently in duplicate. Random‐effects meta‐analyses of mean differences (MDs) or relative risks (RRs) with their 95% confidence intervals (CIs) were conducted, followed by sensitivity analyses, and the GRADE analysis of the evidence quality. A total of 24 papers (23 trials) were included, assessing preventive measures applied either around orthodontic brackets (21 trials; 1427 patients; mean age 14.4 years) or molar bands (2 trials; 46 patients; age/sex not reported). Active patient reminders were associated with reduced WSL incidence on patient level compared to no reminder (3 trials; 190 patients; RR: 0.4; 95% CI: 0.31‐0.64; Number Needed to Treat [NNT]: 3 patients), flat surface sealants were associated with reduced WSL incidence on tooth level than no sealant (5 trials; 2784 teeth; RR: 0.8; 95% CI: 0.63‐0.95; NNT: 33 teeth), and fluoride varnish was associated with reduced WSL severity on tooth level (2 trials; 1160 teeth; MD: −0.32 points; 95% CI: −0.44 to −0.21 points). However, the quality of evidence was low according to GRADE, due to risk of bias. Some evidence indicates that active patient reminders and flat surface sealants or fluoride varnish around orthodontic brackets might be associated with reduced WSL burden, but further research is needed.

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“…catechins, benzalkonium chloride, chlorhexidine, triclosan, zinc oxide, silver nanoparticles, titanium dioxide, quaternary ammonium compounds). Results of in vitro tests, however, are inconclusive as far as sufficiently confirming their clinical usefulness [3,4]. Another solution proposed by research teams is introduction of bioactive glass (BAG) into the composition of orthodontic adhesives.…”

Section: Modification Of Functional Features Of Orthodontic Adhesive mentioning

confidence: 99%

Orthodontic adhesive systems –over half a century of research and experience

Kuśmierczyk¹,

Małkiewicz²

2019

jos

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A B S T R AC TNowadays, during orthodontic treatment, brackets of fixed appliances are attached directly to tooth enamel. Research on development and improvement of orthodontic adhesives has been going on for over 50 years and is progressing in many directions. As a result, new solutions are introduced into clinical practice to improve functionality of adhesive systems being applied. Demands set for an adhesive system dedicated to orthodontic use, are primarily: ability to transfer orthodontic forces onto teeth in three spatial dimensions, resistance to masticatory forces, resistance to oral environment, ability to accurately position brackets and maintain them throughout treatment, possibility of detaching brackets without causing damage to tooth enamel and biocompatibility. Products available on the market do not constitute a homogeneous group in terms of both chemical structure and functional features. This paper presents the history of development of orthodontic adhesive systems and their features in relation to clinical use. Attention was also paid to directions of evolution of the aforementioned group of materials aimed at improving their performance in certain aspects of medical practice. Despite the ongoing research and development work, no orthodontic adhesive system that meets all the requirements set for "ideal material" has been developed to date. Orthodontic adhesives introduced into the market require assessment of their actual clinical usability and safety in treatment of patients.

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Efficacy of antimicrobial agents incorporated in orthodontic bonding systems: a systematic review and meta-analysis

Abstract: Although there is evidence of antibacterial activity from in vitro studies, clinical and long-term studies are still necessary to confirm the effectiveness of antibacterial orthodontic bonding systems in preventing caries disease.

Cited by 27 publications

References 42 publications

Bonding Strength of Universal Adhesives to Indirect Substrates: A Meta‐Analysis of in Vitro Studies

Bonding Strength of Universal Adhesives to Indirect Substrates: A Meta‐Analysis of in Vitro Studies

Prevention of orthodontic enamel demineralization: A systematic review with meta‐analyses

Orthodontic adhesive systems –over half a century of research and experience

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