Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota

Pflug, Natali; Kluth, Sandra; Vehreschild, J. J.; Bahlo, Jasmin; Tacke, Daniela; Biehl, Lena M; Eichhorst, Barbara; Fischer, Kirsten; Cramer, Paula; Fink, Anna‐Maria; Bergwelt‐Baildon, Michael von; Stilgenbauer, Stephan; Hallek, Michael; Cornely, Oliver A.; Vehreschild, Maria J. G. T.

doi:10.1080/2162402x.2016.1150399

Cited by 101 publications

(71 citation statements)

References 15 publications

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“…An additional study found that patients receiving cyclophosphamide for chronic lymphocytic leukaemia who received antimicrobials with a Gram‐positive spectrum had significantly reduced progression free and overall survival times compared to those receiving primarily Gram‐negative spectrum antimicrobials or no antimicrobials at all. This finding is suspected to be related to alterations in the microbiome as discussed above …”

Section: Choice Of Antimicrobialmentioning

confidence: 90%

Antibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendations

Bisson

Argyle

2018

Vet Comparative Oncology

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Bacterial infection following cancer chemotherapy-induced neutropenia is a serious cause of morbidity and mortality in human and veterinary patients. Antimicrobial prophylaxis is controversial in the human oncology field, as any decreased incidence in bacterial infections is countered by patient adverse effects and increased antimicrobial resistance. Comprehensive guidelines exist to aid human oncologists in prescribing antimicrobial prophylaxis but similar recommendations are not available in veterinary literature. As the veterinarian's role in antimicrobial stewardship is increasingly emphasized, it is vital that veterinary oncologists implement appropriate antimicrobial use. By considering the available human and veterinary literature we present an overview of current clinical practices and are able to suggest recommendations for prophylactic antimicrobial use in veterinary cancer chemotherapy patients.

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Section: Choice Of Antimicrobialmentioning

confidence: 90%

Antibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendations

Bisson

Argyle

2018

Vet Comparative Oncology

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“…Likewise, Viaud et al observed that receipt of antibiotics with activity against Gram-positive bacteria reduced T-helper lymphocyte and lymphoma responses in mice treated with cyclophosphamide [17]. Beyond animal models, recently it was shown that patients being treated with cyclophosphamide for chronic lymphocytic leukemia and cisplatin for relapsed lymphoma who also received anti-Gram-positive antibiotics had significantly lower overall response rate and survival [18]. …”

Section: How Antibiotic-induced Microbiome Alteration Affects the Canmentioning

confidence: 99%

Can Consideration of the Microbiome Improve Antimicrobial Utilization and Treatment Outcomes in the Oncology Patient?

Galloway-Peña

Jenq

Shelburne

2017

Clinical Cancer Research

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The need to provide effective and timely antimicrobial treatment to cancer patients with infections is well-recognized, but tempered by preliminary, but accumulating, evidence that antibiotic-induced microbiome dysbiosis affects cancer therapy response, non-infectious toxicities, and infectious complications. Given only a minority of empirically treated cancer patients are proven to have a true bacterial infection, it is important to consider the potential negative consequences of extensive broad-spectrum antimicrobial use on the commensal microbiota. Herein, we review the literature substantiating the dilemma oncologists face when treating suspected or documented infections with respect to the interaction between the host microbiome, antibiotics, and cancer-related clinical outcomes. We propose microbiome-based explorations that could assist oncologists in optimizing treatment strategies for cancer-related infections as well as the cancer, itself. In addition, we discuss knowledge gaps and challenges in this nascent field that must be addressed in order to deliver medically relevant translational applications. We anticipate the emerging knowledge regarding the role of the microbiota in the health of cancer patients may cause a reappraisal of the manner in which antibiotics are used in the oncologic setting and how microorganisms are viewed by oncologists.

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“…В клинических исследованиях при лечении больных хроническим лимфолейкозом (исследование CLL8, схемы FCR и FC; n = 800) и рецидивирующими КЛИНИЧЕСКАЯ ОНКОГЕМАТОЛОГИЯ лимфомами (схемы с цисплатином, n = 122) также было показано негативное влияние антибиотиков против грамположительных бактерий на противоопу-холевый эффект циклофосфамида и цисплатина [59]. У пациентов, получавших анти-грамположительные антибиотики, отмечено ухудшение общего ответа (42,9 vs 70,3 %; p = 0,016), снижение медианы выжи-ваемости без прогрессирования (ВБП; 2,3 vs 11,5 мес.…”

Section: профилактика нарушений микробиотыunclassified

Supportive (Maintenance) Therapy in Hematopoietic Stem Cell Transplantation: Main Principles and New Perspectives

Поп¹,

Рукавицын²

2017

Клиническая онкогематология

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РЕФЕРАТСопроводительная (поддерживающая) терапия (СТ) при трансплантации гемопоэтических стволовых клеток (ТГСК) переживает значительное развитие и изменения. Целью обзора является суммирование основных дан-ных о методах и перспективе СТ при ТГСК, анализ новых возможностей, а также развивающихся альтернативных подходов, усиливающих эффективность противоопухо-левого потенциала ТГСК. Потребность в СТ постоянно возрастает в силу как увеличения количества прово-димых ТГСК, так и возрастания числа живущих после ТГСК. В обзоре освещены традиционные методы СТ, благодаря которым стали возможны успехи ТГСК: анти-бактериальная, противогрибковая и противовирусная профилактика. Кроме того, рассматриваются вопросы специфической профилактики, такие как возможности предупреждения токсичности криоконсерванта диме-тилсульфоксида, а также еще недостаточно изученные аспекты вакцинации реципиентов ТГСК и особенности воздействия на микробиоту. Продемонстрировано, что многие классические рекомендации СТ подлежат пере-смотру с учетом широкой вариативности подходов не только к посттрансплантационному мониторингу, но и к эмпирической антибактериальной терапии, тактике при-менения гемопоэтических факторов роста, целесообраз-ности коррекции микробиоты, ограничений внешней среды и социальных контактов. В настоящее время ТГСК может быть выполнима намного более часто, чем ранее, в условиях, близких к амбулаторным, что приводит к улучшению исходов лечения без необходимости значи-тельных затрат на СТ в стационаре. Повышение эффек-тивности использования ресурсов и качества СТ в буду-щем возможно на основе медицинских информационных технологий и улучшения цифровой инфраструктуры между врачом и пациентом. Представлен собственный опыт СТ при аллоТГСК у 19 пациентов и СТ при аутоТГСК у 82 больных, а также опыт проведения аутоТГСК в не-изолированных палатах без HEPA-фильтрации. Анализ литературы свидетельствует как о повышенной востре-бованности различных методов СТ при ТГСК, так и о воз- ABSTRACTSupportive (maintenance) therapy (ST) for hematopoietic stem cell transplantation (HSCT) is undergoing signifi cant changes and development. The aim of the review was to summarise the basic data on methods and perspective of ST for HSCT and to analyse new opportunities and alternative approaches to enhance the antitumor potential of HSCT. The need for ST is constantly growing as a result of significant increase in the number of performed HSCT and an increase in patient survival. The review highlights traditional methods of ST which allowed to boost the success of HSCT: antibacterial, antifungal, and antiviral preventive treatment. The authors discuss preventing toxicity of dimethyl sulfoxide (cryopreserving agent); understudied aspects of vaccination of HSCT recipients, and eff ects on microbiota. The study demonstrates that many of the classic recommendations of ST are being constantly updated given the wide variability of approaches not only to post-transplant monitoring, but also to empirical antibiotic therapy and the use of hematopoietic growth factor...

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Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota

Cited by 101 publications

References 15 publications

Antibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendations

Antibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendations

Can Consideration of the Microbiome Improve Antimicrobial Utilization and Treatment Outcomes in the Oncology Patient?

Supportive (Maintenance) Therapy in Hematopoietic Stem Cell Transplantation: Main Principles and New Perspectives

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