Efficacy of antiviral therapy in patients with hemophilia and hepatitis C virus infection

Kostić, Velimir; Djordjevic, Marina; Popović, Lidija; Kostić, E.; Djordjevic, Jovana; Govedarevic, Nenad

doi:10.2298/mpns0904129k

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…8 In underdeveloped countries such as Serbia, hemophilia treatment was administered with restrictive protocols, cryoprecipitates, or fresh-frozen plasma, made from a much smaller pool of blood donors who were part of the local community. 14 Spontaneous HCV clearance (seroconversion) is confirmed using two consecutive HCV RNA tests in the span of 6 months. Patients with spontaneous HCV clearance were defined as PwH with positive anti-HCV antibodies and negative HCV RNA (HCV Ab+/RNA-) without prior antiviral therapy.…”

Section: Discussion the Prevalence Of Hcv Infection In Personsmentioning

confidence: 99%

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Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Ruzic

Rajic

Fabri

et al. 2021

Mediterr J Hematol Infect Dis

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Background: Treating HCV in people with hemophilia not only prevents the development of ESLD and HCC, but it also greatly increases the quality of life for people living with hemophilia. There are many obstacles in reaching the WHO goal of globally eradicating HCV by the year 2030., mainly its scale, complexity and implementation. That is why many countries have implemented a micro-elimination strategy: a pragmatic elimination approach in populations with the most efficacy. The aim of this publication is to present the morbidity and mortality rates, the clinical course and treatment outcomes of chronic HCV infection in PWH, as well as to show an example of a successfully conducted HCV micro-elimination strategy among people with hemophilia in the Province of Vojvodina. Methods: A retrospective, single-center study, performed using medical documentation of all registered PWH in the Clinical center of Vojvodina from 1994. until 2020. It included 74 hemophilia patients, out of which 32 were patients with hemophilia and chronic HCV infection. Results: The mean age of HCV positive PWH was 42.3 years, with the duration of infection of 30-35 years. Co-infection with HIV was observed in 6.25% of cases. Furthermore, 18.75% of patients had spontaneous HCV elimination and 75% patients were treated with antiviral protocols. Cirrhosis developed in 21.87% with an incidence rate of 0.6 per 100 patient-years. After treatment with Pegylated IFN and ribavirin (RBV), 58.3% achieved SVR. Side effects of IFN-based therapy regiment were recorded in 20.8% of treated PWH. In 37.5% PWH, DAA protocols were administered, and these patients achieved SVR. HCV positive PWH have a statistically higher mortality rate than non-infected people with hemophilia. Among the HCV positive PWH, hemophilia-related deaths were 6.25%, and HCV-related deaths were 9.37%. Currently, in the Registry of PWH in Vojvodina, there are no patients with active HCV infection. Conclusion: The micro-elimination strategy in subpopulation of PWH was successfully implemented in the Province of Vojvodina in close collaborations of hematologist and infectious diseases specialist.

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Section: Discussion the Prevalence Of Hcv Infection In Personsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Ruzic

Rajic

Fabri

et al. 2021

Mediterr J Hematol Infect Dis

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“…Neželjeni efekti u vidu depresije i psihoze nisu bili registrovani, u toku tri godine praćenja naših bolesnika, što su opisali i drugi autori [13,15] i što je moglo biti razlog za prekid terapije. Zbog laboratorijskih i kliničkih nusefekata smo morali da promenimo doze PEG-IFN i ribavirina kod nekih bolesnika, slično procedurama drugih autora [8,13,16]. Modifikacije lekova su trajale sve do nestanka neželjenih efekata.…”

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Side effects of antiviral therapy in patients with chronic hepatitis C infection

Kostić

Jovanović

Radović³

et al. 2012

Med pregl

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Fate of Patients With Late-Detected Hepatitis C Infection - Case Reports

Kostić¹,

Petrović²,

Radović³

et al. 2011

amm

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Efficacy of antiviral therapy in patients with hemophilia and hepatitis C virus infection

Abstract: HCV positive patients with hemophilia could be successfully treated with combination therapy of peginterferon alfa-2a and ribavirin.

Cited by 3 publications

References 15 publications

Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Side effects of antiviral therapy in patients with chronic hepatitis C infection

Fate of Patients With Late-Detected Hepatitis C Infection - Case Reports

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