Efficacy of Apixaban on Thrombus Resolution and Anti-Inflammation in a Murine Model of Acute Deep Venous Thrombosis

Stapler, Stevie-Jay; Farris, Diana M.; Luke, Catherine E.; Díaz, José; Henke, Peter K.; Wakefield, Thomas W.; Ballard-Lipka, N.

doi:10.1016/j.jvsv.2015.10.019

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Thromboinflammation As a Therapeutic Target To Prevent DCI1

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2017

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“…The SoSTART trial is set to investigate seven anti-coagulants for therapeutic benefit in patients of cerebral hemorrhage, including aSAH. These proposed drugs are known to be reduce coagulability and prevent inflammation ( 118 , 119 ), which may reduce the overall thromboinflammation.…”

Section: Thromboinflammation As a Therapeutic Target To Prevent DCImentioning

confidence: 99%

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

et al. 2017

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Delayed cerebral ischemia (DCI) is a major determinant of patient outcome following aneurysmal subarachnoid hemorrhage. Although the exact mechanisms leading to DCI are not fully known, inflammation, cerebral vasospasm, and microthrombi may all function together to mediate the onset of DCI. Indeed, inflammation is tightly linked with activation of coagulation and microthrombi formation. Thromboinflammation is the intersection at which inflammation and thrombosis regulate one another in a feedforward manner, potentiating the formation of thrombi and pro-inflammatory signaling. In this review, we will explore the role(s) of inflammation and microthrombi in subarachnoid hemorrhage (SAH) pathophysiology and DCI, and discuss the potential of targeting thromboinflammation to prevent DCI after SAH.

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Section: Thromboinflammation As a Therapeutic Target To Prevent DCImentioning

confidence: 99%

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

et al. 2017

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show abstract

Efficacy of Apixaban on Thrombus Resolution and Anti-Inflammation in a Murine Model of Acute Deep Venous Thrombosis

Cited by 1 publication

References 0 publications

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

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