Efficacy of Artemisia annua Linné in improving cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia animal model

Kim, Seo-Young; Kim, Youn-Jung; Cho, Seung‐Yeon; Lee, Han-Gyul; Kwon, Seungwon; Park, Seong-Uk; Jung, Woo-Sang; Moon, Sang-Kwan; Park, Jung‐Mi; Cho, Ki-Ho; Ko, Chang-Nam

doi:10.1016/j.phymed.2023.154683

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Sfn has proven effective in protecting BBB in stroke and TBI models [144]. Importantly, such a protective effect of Sfn is lacking in NRF2 knockdown mice, supporting a pivotal role of NRF2 in the protection of the BBB [143,145]. Mechanistically, NRF2 directly acts on the promoters of the claudin-5 and VE-cadherin genes, as evidenced by promoter analysis and promoter activity studies [134,144].…”

Section: Neurovascular Coupling (Nvc)mentioning

confidence: 96%

“…Interestingly, in a study with a VCID rat model, oral administration of Artemisia annua Linné, a plant harboring antioxidant properties, helped to maintain BBB integrity by increasing platelet-derived growth factor (PDGF) receptor β and platelet-endothelial CAM-1 levels associated with NRF2/Keap1 pathway [145], although CAMs are generally believed to be inflammatory markers and may lead to BBB breakdown.…”

Section: Neurovascular Coupling (Nvc)mentioning

confidence: 99%

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The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID)

Hu,

Zhang,

Ikonomovic

et al. 2024

IJMS

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Vascular cognitive impairment and dementia (VCID) represents a broad spectrum of cognitive decline secondary to cerebral vascular aging and injury. It is the second most common type of dementia, and the prevalence continues to increase. Nuclear factor erythroid 2-related factor 2 (NRF2) is enriched in the cerebral vasculature and has diverse roles in metabolic balance, mitochondrial stabilization, redox balance, and anti-inflammation. In this review, we first briefly introduce cerebrovascular aging in VCID and the NRF2 pathway. We then extensively discuss the effects of NRF2 activation in cerebrovascular components such as endothelial cells, vascular smooth muscle cells, pericytes, and perivascular macrophages. Finally, we summarize the clinical potential of NRF2 activators in VCID.

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