Efficacy of artesunate and praziquantel in Schistosomahaematobium infected schoolchildren

Clercq, Dominique De; Vercruysse, Jozef; Kongs, A; Verlé, Paul; Dompnier, Jean-Pierre; Faye, Pc

doi:10.1016/s0001-706x(02)00003-7

Cited by 66 publications

(36 citation statements)

References 18 publications

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“…These values are in general within the usual cure rate ranges (63-95%) of PZQ against S. mansoni reported in different epidemiological settings [4,[26][27][28] . Some previous studies have reported efficacy higher than 85% for PZQ [29][30][31][32][33][34] , while others have reported lower (<63%) efficacy for the drug [13][14][15][16][17][18][19][20][21]35,36] . Such variations might be attributable to differences in the number of treatment, factors related to the host, parasite, and drugs or to the methodology.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, infected children younger than 10 years and in the 10-14 age group showed high percent of heavy and moderate infection and low cure rate after treatment as compared to those in the [15][16][17][18][19][20][21][22] age group. This agrees with similar previous studies [16,36,43] in which significant association between classes of intensity and age groups was observed.…”

Section: Discussionmentioning

confidence: 99%

“…The present study area is an area of intense transmission where school age children acquire heavy infection. In the [15][16][17][18][19][20][21][22] age group, lower intensity and prevalence of S. mansoni infection and high cure rate after treatment may be explained by reduced exposure to cercariae infested water and maturing acquired immunity with age. The difference in the drug efficacy among the different age groups could also be due to absence of linear relationship between body weight and dose of PZQ [21] .…”

Section: Discussionmentioning

confidence: 99%

“…Asian Pacific Journal of Tropical Biomedicine journal homepage:www.elsevier.com/locate/apjtb efficacy [13][14][15][16][17][18][19][20][21] . In addition, the expiry of patent protection for the major anthelminthic drugs [10,22] and international competition that has substantially reduced the price of the drug [23] have made several low-cost brands and generic formats of PZQ available on the market.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…The evaluated generic PZQ produced an overall cure rate of 73.6% (P<0.000 1, OR: 8.33, CI: 5.3-13.1) and egg reduction rate of 68.2% (P=0.03, F=0.64). The cure rate showed significant association with age ( 氈 2 =11, P=0.004), the highest rate being observed in the [15][16][17][18][19][20][21][22] age group. 83% of S. mansoni infected children showed various treatment-related symptoms, the most frequent being headache, nausea, and abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia

Erko

Degarege

Tadesse

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia

Erko

Degarege

Tadesse

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Drugs for treating urinary schistosomiasis

Danso‐Appiah¹,

Utzinger²,

Liu³

et al. 2008

Cochrane Database of Systematic Reviews

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Analysis 2.4. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 4 Haematuria at three months...... Analysis 2.5. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 5 Proteinuria at three months....... Analysis 2.6. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 6 Haematuria at six weeks........... Analysis 2.7. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 7 Proteinuria at six weeks............ Analysis 2.8. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 8 Haematuria at nine months....... Analysis 2.9. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 9 Proteinuria at nine months........ Analysis 2.10. Comparison 2 Praziquantel 40 mg/kg single dose versus lower doses, Outcome 10

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Drugs for treating urinary schistosomiasis

Kramer

Zhang

Sinclair

et al. 2014

Cochrane Database of Systematic Reviews

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Background Urinary schistosomiasis is caused by an intravascular infection with parasitic Schistosoma haematobium worms. The adult worms typically migrate to the venous plexus of the human bladder and excrete eggs which the infected person passes in their urine. Chronic infection can cause substantial morbidity and long‐term complications as the eggs become trapped in human tissues causing inflammation and fibrosis. We summarised evidence of drugs active against the infection. This is new edition of a review first published in 1997. Objectives To evaluate the efficacy and safety of drugs for treating urinary schistosomiasis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, MEDLINE, CENTRAL, EMBASE and LILACS and reference lists of articles up to 23 May 2014. Selection criteria Randomized controlled trials (RCTs) of antischistosomal drugs and drug combinations compared to placebo, no intervention, or each other. Data collection and analysis Two researchers independently screened the records, extracted the data and assessed risk of bias. The primary efficacy outcomes were parasitological failure (defined as the continued presence of S. haematobium eggs in the urine at time points greater than one month after treatment), and percent reduction of egg counts from baseline. We presented dichotomous data as risk ratios (RR), and continuous data as mean difference (MD), alongside their 95% confidence intervals (CIs). Where appropriate we combined trials in meta analyses or tables. We assessed the quality of evidence using the GRADE approach. Main results We included 30 RCTs enrolling 8165 participants in this review. Twenty‐four trials were conducted in children in sub‐Saharan Africa, and 21 trials were over 20 years old. Many studies were assessed as being at unclear risk of bias due to inadequate descriptions of study methods. Praziquantel On average, a single 40 mg/kg dose of praziquantel reduced the proportion of people still excreting eggs in their urine by around 60% compared to placebo at one to two months after treatment (treatment failure: RR 0.42, 95% CI 0.29 to 0.59, 864 participants, seven trials, high quality evidence ). The proportion of people cured with praziquantel varied substantially between trials, from 22.5% to 83.3%, but was higher than 60% in five of the seven trials. At one to two months following praziquantel treatment at 40 mg/kg, the mean number of schistosome eggs in the urine was reduced by over 95% in five out of six trials (678 participants, six trials, high quality evidence ). Splitting praziquantel 40 mg/kg into two doses over 12 hours probably has no benefits over a single dose, and in a single trial of 220 participants the...

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Efficacy of artesunate and praziquantel in Schistosomahaematobium infected schoolchildren

Cited by 66 publications

References 18 publications

Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia

Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia

Drugs for treating urinary schistosomiasis

Drugs for treating urinary schistosomiasis

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