Efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion: A cohort study

Abstract

Objective To assess the efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion (URSA). Methods Data were reviewed from women with early RSA attending a hospital in Beijing, China, 2013–2017. Those with no abnormal indices (e.g., endocrine, coagulation, immune, genetic) were diagnosed as having URSA, and received aspirin, prednisone, and multivitamin therapy (triple therapy group, n=106) or folic acid monotherapy (control group, n=65). Treatment efficacy was evaluated as the rate of successful treatment (12‐week pregnancy with obvious embryo and embryonic heart, nuchal translucency thickness <0.25 cm, size consistent with gestational age, no early malformation). Results Overall, 362 women had early RSA and 171 (47.2%) had URSA. The rate of successful pregnancy was similar between the triple therapy (89.6%) and control (92.3%) groups (P=0.343). The rate of successful treatment was higher in the triple therapy (86.3%) than in the control (53.3%) group (P<0.001). In multivariate logistic regression analysis, triple therapy was associated with higher odds of successful treatment, whereas the number of spontaneous pregnancy losses was associated with lower odds of successful treatment. Conclusion The triple therapy of aspirin, prednisone, and multivitamin was found to be a good treatment option for women with URSA.

Low‐dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss

“…Other studies found that the combined use of aspirin and calheparin or prednisone is associated with increased rates of achieving first-trimester pregnancy. 17,18 However, it is unknown how LDA intake can improve the pregnancy outcome for URPL patients.…”

The Efficacy of Traditional Chinese Medicine Shoutai Pill Combined with Western Medicine in the First Trimester of Pregnancy in Women with Unexplained Recurrent Spontaneous Abortion: A Systematic Review and Meta-Analysis

“…Emerging evidence shows that immunological disturbances and abnormal coagulation and anticoagulation may be involved in this disorder [ 7 , 8 ]. Various therapeutic strategies such as immunologic intervention with allogenic lymphocyte [ 9 ] and immunoglobulin [ 10 ], anticoagulant therapy using aspirin [ 11 ] or low-molecular weight heparin [ 12 ], hormonal supplementation with progesterone or dydrogesterone [ 13 ], and microelements supplementation, such as vitamin E, vitamin D [ 14 ], and folic acid [ 15 ], have been used to improve pregnancy outcomes among these women, but no effective treatment has been identified. To date, there is no widely accepted therapeutic approaches for URSA [ 16 ], bringing seriously physical and mental impacts to both the affected female population and their families [ 17 – 19 ].…”

Immunotherapy for Recurrent Pregnancy Loss: A Review

“…They thus concluded that the triple therapy of aspirin, prednisone, and multivitamin was a good treatment option for women with unexplained recurrent spontaneous abortions. [17] So, currently there are studies which show that corticosteroids do have an effect on reducing the NK cell concentration that is raised in recurrent miscarriage patients. But treatment offers a doubtful increase in the live birth rate although it reduces the concentration of the NK cells.…”