Efficacy of azithromycin 1.5% eyedrops vs oral doxycycline in meibomian gland dysfunction: a randomized trial

Satitpitakul, Vannarut; Ratanawongphaibul, Kitiya; Kasetsuwan, Ngamjit; Reinprayoon, Usanee

doi:10.1007/s00417-019-04322-1

Cited by 14 publications

(26 citation statements)

References 19 publications

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“…Blepharitis, Meibomian gland dysfunction, and other ocular diseases lead to dry eye due to decreased secretions. 20 – 22 Three RCTs 6 , 15 , 16 were found to report the effect of azithromycin on improving Meibomian gland secretion. The pooled estimate of the studies revealed that patients treated with azithromycin showed statistically significant improvement in Meibomian gland secretion with an SMD of −1.78 (95% CI: −2.25, −1.30).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of azithromycin 1% and 1.5% ophthalmic solutions compared to tobramycin 0.3% eye drops: A systematic review and meta-analysis

Motbaynor

Worku

2020

SAGE Open Medicine

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Background: Azithromycin 1% and 1.5% ophthalmic preparations are used widely in clinical practice for the treatment of signs and symptoms of eye diseases. The aim of this study was to render conclusive evidence by comparing the efficacy of azithromycin 1% and 1.5% over tobramycin 0.3% ophthalmic solutions for the treatment of eye diseases in a short duration in terms of bacterial resolution, the cure rate, and resolving clinical sign and symptoms. Methods: Systematic searches were performed in the electronic database (MEDLINE, Embase, Emcare, CINAHL, Scopus, PubMed, ProQuest, and Web of Science) and other sources. Multicenter randomized controlled trial studies conducted in English were identified and screened. Analysis of individual studies was conducted using the OpenMeta-analyst and Review Manager Version 5.3 software. Results: Eleven studies were included in the systematic review and meta-analysis. In clinical cure rate, azithromycin 1% and 1.5% eye drops were more effective than tobramycin 0.3% eye drops in short duration dosing (⩽5 days) with a twice-a-day regimen (relative risk = 1.13; 95% confidence interval: 1.008, 1.28), whereas on increased duration (>5 days), azithromycin is almost similarly as effective as tobramycin (relative risk = 1.007; 95% confidence interval: 0.96, 1.05). There was no significant difference in efficacy of bacterial resolution of azithromycin (1%, 1.5%) eye drops compared to tobramycin (0.3%) eye drops (relative risk = 0.99; 95% confidence interval: 0.96, 1.018). Azithromycin eye drops are effective in improving the signs and symptoms of eye disease. Conclusion: Azithromycin 1% or 1.5% is more effective in the clinical cure rate of eye disease than tobramycin 0.3% eye drops in ⩽5 days of treatment. It is also the best choice of treatment for improving the signs and symptoms of eye disease. So that we recommend clinicians to use azithromycin 1% or 1.5% eye drops. Systematic Review Registration: PROSPERO 2019 CRD42019139911

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Section: Resultsmentioning

confidence: 99%

Efficacy of azithromycin 1% and 1.5% ophthalmic solutions compared to tobramycin 0.3% eye drops: A systematic review and meta-analysis

Motbaynor

Worku

2020

SAGE Open Medicine

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“…Of these, 22 articles met the inclusion criteria and were used in the final analysis of this review based on the full-text contents. The final 22 studies included twelve randomized controlled trials (RCTs) [25,36,39,40,[46][47][48][49][50][51][52][53], nine non-randomized prospective studies [41,[54][55][56][57][58][59][60][61], and one retrospective study [62]. The studies were published between April 2003 [61], and January 2021 [51], and were conducted in Eleven different countries: Brazil [41], USA [48,50,54,55,[58][59][60][61], France [56], Spain [39], Italy [57], Turkey [49,52,62], Iran [40,53], Lebanon [25], Korea [36,46], Japan [51], and Thailand [47].…”

Section: Review Of Existing Literaturementioning

confidence: 99%

“…The most common duration of treatment for oral antibiotics was five days for azithromycin [39][40][41]49], one month for doxycycline [39,40,[46][47][48]57,60], and three months for minocycline [36,56,58,61]. Topical azithromycin was most often used for four weeks [25,47,49,50,52,54,55,59,62].…”

Section: Treatment Duration and Follow-upmentioning

confidence: 99%

“…Eleven studies had the final follow-up at the end of treatment [36,[46][47][48]50,51,53,54,56,57,60]. Ten other studies had a follow-up time between one week to three months after ending of treatment [25,40,41,49,52,55,58,59,61,62].…”

Section: Treatment Duration and Follow-upmentioning

confidence: 99%

“…All formulations of antibiotics were effective in alleviating subjective symptoms and no study found a greater improvement in symptoms with one formulation over another [40,46,47,49,53,60]. However, one study, on patients with severe MGD, found that symptoms improved significantly more when topical azithromycin was used in conjunction with systemic azithromycin than systemic azithromycin alone [52].…”

Section: Changes In Subjective Measuresmentioning

confidence: 99%

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