Efficacy of Berberine Chloride on Hyperglycemia in Streptozotocin Induced Diabetic Rats

Abstract

The aim of this study to find out the perfect dose of Berberine chloride (BC) in streptozotocin (STZ) induced diabetic rats by observation of effect of BC on blood glucose, plasma insulin, glycated hemoglobin and hemoglobin. Experimental diabetes was induced in rats by a single dose of intraperitonial injection of streptozotocin (40 mg/kg b.w). After the 72 hours, diabetic rats treated with BC at different concentrations (25. 50 and 100 mg/kg b.w) for 45 days. BC administration significantly declined the levels of blood glucose, glycated hemoglobin and renal markers whereas elevated the levels of plasma insulin, hemoglobin and body weight in diabetic rats. 50 mg/kg b.w of BC showed the prominent effect compared to other two doses. From these results clearly shows the antidiabetic activity of BC.

Reducing Effects of Aerobic Exercise Training Combined with Berberine Chloride Supplementation on the Apoptotic Markers of Kidney in Streptozotocin-Induced Diabetic Male Rats

“…Another study also demonstrated that chronic BC treatment had a beneficial effect on synaptic dysfunction and anti-apoptotic properties in STZ-diabetic rats (22). Chandirasegaran et al, investigated the efficacy of different concentrations of BC (25, 50, and 100 mg/kg) on hyperglycemia in STZ-induced diabetic rats and reported that 50 mg/kg of BC would reduce blood glucose, glycation of hemoglobin, and levels of renal markers (12). Based on the studies, the molecular mechanisms undertaking BC against diabetes mellitus include lipid and glucose metabolism, and antioxidant and anti-inflammatory activities that have therapeutic activities against diabetes mellitus and insulin resistance (23)(24)(25).…”

“…BC supplement (Sigma Aldrich, USA) was administrated every day via gavage. Diabetic rats were treated with 15 and 30 mg/kg of BC (12) and at the end of each week, after weighting the rats, the amount of solution was calculated based on the weight of rats. BC doses of 15 and 30 mg/kg were completely dissolved in 0.3 and 0.6 mL of normal saline, respectively.…”

“…On the other hand, it is a long time that plants are the sources of various medicines as an effective strategy for prevention and therapy (12). Berberine chloride (BC) is a plant alkaloid, present in many medicinal plants, which has many pharmacological activities (12).…”

“…On the other hand, it is a long time that plants are the sources of various medicines as an effective strategy for prevention and therapy (12). Berberine chloride (BC) is a plant alkaloid, present in many medicinal plants, which has many pharmacological activities (12). Chandirasegaran et al, showed that anti-apoptotic (Bcl-2) protein increased and pro-apoptotic (Bax) protein decreased in the liver of streptozotocin (STZ)-induced diabetic rats treated with BC (13).…”

Antidiabetic Potential of Perillyl Alcohol, a Monoterpene on High-Fat Diet Low-Dose Streptozotocin-Induced Diabetes in Experimental Rats

“…DM is associated with loss of BW, polyuria (frequent urination), polydipsia (frequent thirst), and polyphagia (frequent hunger) [28]. In T2DM energy metabolism in liver tissue is impaired that enables low energy state to stimulate satiety center that in turn increases food intake [29].…”