Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

Zhong, Siyang; Su, Huan; Li, Chenyang; Lin, Yiqin; Lu, Wei; Jiang, Zhendong; Yang, Lin

doi:10.34133/2022/9759265

Cited by 15 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By alloy materials with better actuating effects [186] and more reasonable driving methods, [187] soft grippers are expected to achieve micrometer-scale targeted medical effects. 2) Structural flexibility and stability: In assistive applications, such as soft grippers used in wearable technology, [188,189] the structural flexibility and stability of the grippers are of great importance. However, wearable systems are more practical application oriented system designs.…”

Section: Application Summary and Future Prospectsmentioning

confidence: 99%

“…In addition, considering the directional operation and micro‐nanoscale properties of targeted therapy, [ 185 ] the application of soft grippers in the micro–nano medical field also requires further breakthroughs in operation accuracy and response speed. By alloy materials with better actuating effects [ 186 ] and more reasonable driving methods, [ 187 ] soft grippers are expected to achieve micrometer‐scale targeted medical effects. 2)Structural flexibility and stability: In assistive applications, such as soft grippers used in wearable technology, [ 188,189 ] the structural flexibility and stability of the grippers are of great importance. However, wearable systems are more practical application oriented system designs.…”

Section: Application and Challengesmentioning

confidence: 99%

See 1 more Smart Citation

Advanced Technologies and Applications of Robotic Soft Grippers

Qu,

Yu,

Tang

et al. 2024

Adv Materials Technologies

View full text Add to dashboard Cite

The robotic soft gripper is a significant and expanding area of study. It is primarily a unique gadget that interacts with the external environment in a certain actuating mode by utilizing the properties of flexible materials and biological shape design. Robotic grippers are increasingly needed in the fields of medical operations, auxiliary maintenance, land rescue, underwater grasping, and space manipulation due to the increasing demand for automation. However, conventional rigid gripper is not the ideal option or optimal design for particular activities requiring a high degree of adaptation and interaction. The soft gripper can interact with its surroundings safely and flexibly because it is comprised of flexible materials. Currently, certain technical system has been developed through research on flexible grippers, but it is still in its infancy. This paper reviews the materials and manufacturing technology, actuating technology, and sensing and control technology of flexible mechanical grippers. Finally, several main application areas of soft grippers are discussed from a technical point of view, as well as possible challenges for further development.

show abstract

Section: Application Summary and Future Prospectsmentioning

confidence: 99%

Section: Application and Challengesmentioning

confidence: 99%

Advanced Technologies and Applications of Robotic Soft Grippers

Qu,

Yu,

Tang

et al. 2024

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

“…Microfluidic systems have been utilized in cell culture more frequently in recent years [17][18][19][20] , particularly in dynamic cell culture systems that imitate the intricate movements of bodily organs [21][22][23][24] . Microfluidic devices allow human manipulation to mimic intricate movements and possess precise dimensions that simplify the process of structural design.…”

Section: Introductionmentioning

confidence: 99%

Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

Zhang,

Wang,

Yin

et al. 2024

Microsyst Nanoeng

View full text Add to dashboard Cite

During cardiac development, mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number, area, and arrangement heterogeneity. However, the response of cells to different degrees of mechanical stimuli is unclear. Organ-on-a-chip, as a platform for investigating mechanical stress stimuli in cellular mimicry of the in vivo microenvironment, is limited by the lack of ability to accurately quantify externally induced stimuli. However, previous technology lacks the integration of external stimuli and feedback sensors in microfluidic platforms to obtain and apply precise amounts of external stimuli. Here, we designed a cell stretching platform with an in-situ sensor. The in-situ liquid metal sensors can accurately measure the mechanical stimulation caused by the deformation of the vacuum cavity exerted on cells. The platform was applied to human cardiomyocytes (AC16) under cyclic strain (5%, 10%, 15%, 20 and 25%), and we found that cyclic strain promoted cell growth induced the arrangement of cells on the membrane to gradually unify, and stabilized the cells at 15% amplitude, which was even more effective after 3 days of culture. The platform’s precise control and measurement of mechanical forces can be used to establish more accurate in vitro microenvironmental models for disease modeling and therapeutic research.

show abstract

“…Electrical stimulation is a type of physical therapy treatment used to accomplish various tasks in physical therapy. According to research on transplanted nerves, it accelerates the regeneration rate of reconstructed peripheral nerves [22,23]. For this reason, it is interesting to assess the response during the process of nerve repair in peripheral neuropathies.…”

Section: Introductionmentioning

confidence: 99%

The Role of Physical Exercise and Rehabilitative Implications in the Process of Nerve Repair in Peripheral Neuropathies: A Systematic Review

Chiaramonte

Pavone²,

Testa³

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Background: The various mechanisms involved in peripheral nerve regeneration, induced by exercise and electrical nerve stimulation, are still unclear. Objective: The aim of this review was to summarize the influence of physical exercise and/or electrical stimulation on peripheral nerve repair and regeneration and the variatio nerve stimulationn of impact of intervention depending on timing, as well as kind and dosage of the intervention. A literature survey was conducted on PubMed, Scopus, and Web of Science, between February 2021 to July 2021, with an update in September 2022. Methodology: The literature search identified 101,386 articles with the keywords: “peripheral nerve” OR “neuropathy” AND “sprouting” OR “neuroapraxia” OR “axonotmesis” OR “neurotmesis” OR “muscle denervation” OR “denervated muscle” AND “rehabilitation” OR “physical activity” OR “physical exercise” OR “activity” OR “electrical stimulation”. A total of 60 publications were included. Eligible studies were focused on evaluating the process of nerve repair (biopsy, electromyographic parameters or biomarker outcomes) after electrical stimulation or physical exercise interventions on humans or animals with peripheral sensory or motor nerve injury. Synthesis: This study shows that the literature, especially regarding preclinical research, is mainly in agreement that an early physical program with active exercise and/or electrical stimulation promotes axonal regenerative responses and prevents maladaptive response. This was evaluated by means of changes in electrophysiological recordings of CMAPs for latency amplitude, and the sciatic functional index (SFI). Furthermore, this type of activity can cause an increase in weight and in muscle fiber diameter. Nevertheless, some detrimental effects of exercising and electrical stimulation too early after nerve repair were recorded. Conclusion: In most preclinical studies, peripheral neuropathy function was associated with improvements after physical exercise and electrical stimulation. For humans, too little research has been conducted on this topic to reach a complete conclusion. This research supports the need for future studies to test the validity of a possible rehabilitation treatment in humans in cases of peripheral neuropathy to help nerve sprouting.

show abstract

Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

Cited by 15 publications

References 26 publications

Advanced Technologies and Applications of Robotic Soft Grippers

Advanced Technologies and Applications of Robotic Soft Grippers

Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

The Role of Physical Exercise and Rehabilitative Implications in the Process of Nerve Repair in Peripheral Neuropathies: A Systematic Review

Contact Info

Product

Resources

About