Efficacy of bivalent fimbrial vaccines to control and eliminate intermediate forms of footrot in sheep

Whittington, Richard J.; Corrigan, Marion; Edmonstone, B I; Cronin, N.B.; Dhand, N K; Dhungyel, Om P.

doi:10.1111/avj.13138

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…However, additional research into the efficacy of vaccines against benign and intermediate footrot is required as virulent footrot has historically been the focus of research (23,62). A recent study in NSW suggested that serogroup-specific vaccination may be used as a tool to control and eliminate intermediate forms of footrot (63). Biosecurity practices are essential in preventing the introduction of diseases at the farm and regional level (64).…”

Section: Discussionmentioning

confidence: 99%

A survey to understand farmers' perceptions and risk factors for hoof diseases including footrot in sheep in New South Wales, Australia

Smith

Whittington²,

Green³

et al. 2022

Front. Vet. Sci.

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The aims of this study were to develop an understanding of farmers' perceptions and risk factors for footrot, including its less severe forms, and other hoof diseases in sheep in New South Wales (NSW). A questionnaire was developed and administered to sheep farmers in Local Land Services (LLS) regions across NSW. LLS staff selected sheep farmers who met the inclusion criteria which included farmers with a minimum of 100 sheep, a history of having had foot problems in their flock or having expressed an interest in improving sheep health and production. Farmers completed the questionnaire either by telephone or via the REDCap online survey platform. Descriptive analyses and multivariable logistic regression models were created. The survey was completed by 43 sheep farmers with a median farm size of 1,500 Ha and flock size of 2,300; footrot was present on 39% of farms while 75.6% had other hoof diseases. A flock of >3,000 sheep were more likely to have footrot than a smaller flock (OR = 11.99, 90% CI = 3.02–63.92, P-value = 0.005) and footrot was less likely to be present on farms when an Animal Health Statement was requested while purchasing sheep (OR = 0.10, 90% CI = 0.01–0.56, P-value = 0.04). Hoof conditions other than footrot were likely to be present in flocks when foot inspections were conducted at a time other than weekly inspections (OR = 0.13, 90% CI = 0.01–0.68, P-value = 0.04) and flocks kept on undulating ground were more likely to have diseases other than footrot compared to those kept on flat ground (OR = 3.72, 90% CI = 1.02–15.80, P-value = 0.09). Most farmers agreed that footrot including its less severe forms can cause production losses and negatively affect animal health and welfare. Limitations of the study were the sample size and dry environmental conditions prior to and during study period in many regions of NSW which limited the expression of footrot.

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Section: Discussionmentioning

confidence: 99%

A survey to understand farmers' perceptions and risk factors for hoof diseases including footrot in sheep in New South Wales, Australia

Smith

Whittington²,

Green³

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…At present, research is focused on developing autovaccines or serogroup-specific vaccines for use during specific footrot outbreaks [ 30 – 33 ]. This approach needs the identification of circulating bacterial strains and serogrouping of D. nodosus circulating in the flock, followed by developing a serogroup-specific vaccine [ 16 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

The prevalence, virulence, and serogroups of Dichelobacter nodosus and prevalence of Fusobacterium necrophorum in footrot lesions of sheep and cattle in Morocco

Bamouh¹,

Elkarhat

Zouagui

et al. 2023

Vet World

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Background and Aim: Footrot is a contagious disease of ruminants leading to severe economic losses. This study aimed to estimate the prevalence, virulence, and serogroups of Dichelobacter nodosus and the prevalence of Fusobacterium necrophorum in footrot lesions of sheep and cattle. Materials and Methods: A total of 106 pathogenic lesion samples were taken from 74 sheep and 32 cattle exhibiting typical footrot lesions and were analyzed for the presence of D. nodosus and F. necrophorum by real-time polymerase chain reaction (PCR). Both virulence and serogroup were estimated for D. nodosus positive samples. Results: Among the 106 samples, 89 were positive by PCR for F. necrophorum, D. nodosus, or both. Dichelobacter nodosus was detected at a rate of 78.3% versus 28.3% for F. necrophorum. Virulent D. nodosus strains were detected in 67.5% of positive samples, with a higher rate in sheep (73.4%) than in cattle (47.4%). Benign D. nodosus strains were detected in 57.8% of samples, with a lower prevalence rate in sheep (50%) than in cattle (84.2%). The positive samples of D. nodosus revealed the presence of three dominant serogroups (D, H, I) and three minor serogroups (G, C, A) by serogroup-specific multiplex PCR. Conclusion: The findings provided information on the prevalence of D. nodosus and F. necrophorum strains in footrot lesions of sheep and cattle in some regions of Morocco, which will be useful for developing an effective autovaccine for the prevention of this disease in cattle and sheep in these regions. Keywords: cattle, Dichelobacter nodosus, footrot, Fusobacterium necrophorum, polymerase chain reaction, sheep.

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Efficacy of bivalent fimbrial vaccines to control and eliminate intermediate forms of footrot in sheep

Cited by 2 publications

References 34 publications

A survey to understand farmers' perceptions and risk factors for hoof diseases including footrot in sheep in New South Wales, Australia

A survey to understand farmers' perceptions and risk factors for hoof diseases including footrot in sheep in New South Wales, Australia

The prevalence, virulence, and serogroups of Dichelobacter nodosus and prevalence of Fusobacterium necrophorum in footrot lesions of sheep and cattle in Morocco

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