Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis

Chopra, Rishi; Vakharia, Paras P.; Sacotte, R.; Silverberg, Jonathan I.

doi:10.1016/j.anai.2017.08.289

Cited by 104 publications

(65 citation statements)

References 36 publications

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“…Although bleach baths are widely accepted as an effective therapy for AD in some areas [36], they still remain highly controversial worldwide. Moreover, bleach baths were not more effective than water baths alone in reducing the severity of AD [37]. Moreover, sometimes the effects of bleach bath were contradictory in human studies.…”

Section: Antibacterial Treatmentmentioning

confidence: 98%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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Atopic dermatitis (AD) is a chronic common inflammatory skin disorder with clinical characteristics of pruritic, dry, and recurrent flares that involve the whole body. Recent studies have demonstrated that the skin microbiota, characterized by an overgrowth of Staphylococcus aureus (S. aureus), plays a critical role in the manifestation of AD. There is striking evidence that skin microbiota can modulate the development and progression of AD. Therefore, more and more therapeutic approaches are adopted for modifying skin microbiota. Here we discuss the role of skin microbiota in the etiology and maintenance of AD; furthermore, we summarize the effects of therapeutic treatments on skin microbiota in AD based on published literature. With the help of the theoretical guidance suggested by microbial metagenome analysis, the reconstitution of microbiota should be a promising way to harness the pathogens of AD and could be used as a brandnew therapeutic strategy in clinical trials. We believe that the targeted therapy of dysbiosis in AD may possibly become a unique approach to an integrated treatment program in the near future.

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Section: Antibacterial Treatmentmentioning

confidence: 98%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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“…A diluted bleach solution (sodium hypochlorite [NaOCl] 0.005%) is often used for this purpose, with conflicting reports of its efficacy to decrease the severity of inflammation or eradicate S aureus on the skin. [2][3][4] In this study we sought to directly test the assumption that NaOCl at concentrations recommended for bleach baths is an effective antibacterial agent.…”

Section: Dilute Bleach Baths Used For Treatment Of Atopic Dermatitis mentioning

confidence: 99%

“…These observations are not intended to directly support or refute the potential benefits of bleach bath therapy but only to dispel the false conclusion that it is a form of antimicrobial therapy. Indeed, because a recent meta-analysis concluded that water baths alone can significantly decrease the severity of atopic dermatitis, 4 beneficial effects can be due to effects other than those acting directly on the skin microbiome. With improved disease, the bacterial burden might indirectly decrease because of enhanced innate antimicrobial functions.…”

Section: Dilute Bleach Baths Used For Treatment Of Atopic Dermatitis mentioning

confidence: 99%

Dilute bleach baths used for treatment of atopic dermatitis are not antimicrobial in vitro

Sawada

Tong

Barangi

et al. 2019

Journal of Allergy and Clinical Immunology

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“…Of note, a recent systematic review found that the addition of bleach as a disinfectant has not been shown to provide further clinical benefit. 60 The act of bathing can have added benefit, including relaxation. 2.…”

Section: Basic Management Of Admentioning

confidence: 99%

Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape

Boguniewicz

Fonacier

Guttman‐Yassky

et al. 2018

Annals of Allergy, Asthma & Immunology

244

217

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The implementation of treatment guidelines for atopic dermatitis is challenging, in part because of different guidance documents being used by different groups of specialists and in part because the language of guidelines often reflects the evidence base rather than the practical "how to." The Atopic Dermatitis Yardstick is part of a series developed in response to the need to proactively address the loss of disease control for atopic illnesses at all levels of severity. It presents a comprehensive update on how to conduct a sustained step-up in therapy for the patient with inadequately controlled or poorly controlled atopic dermatitis. Patient profiles, based on current guidelines and the authors' combined clinical experience, provide a practical and clinically meaningful guide to aid physicians in helping their patients achieve the goal of clear to almost clear. The intent is not to replace guidelines but to complement their recommendations incorporating the latest research and therapies.

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Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis

Abstract: Although bleach baths are effective in decreasing AD severity, they do not appear to be more effective than water baths alone. Future larger-scale, well-designed randomized controlled trials are needed.

Cited by 104 publications

References 36 publications

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Dilute bleach baths used for treatment of atopic dermatitis are not antimicrobial in vitro

Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape

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