Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion

Namin, Arya W.; Bruggers, Seth D.; Panuganti, Bharat; Christopher, Kara M.; Walker, Rebecca; Varvares, Mark A.

doi:10.1002/lary.25063

Cited by 23 publications

(27 citation statements)

References 33 publications

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“…Mortality rates and treatment -related morbidity of patients with OSCC are still exceedingly high, challenging the available methods of diagnostic and prognostic assessment, and encouraging the search for new and better tools, namely molecular markers that relate comprehensively to known characteristics of tumor progression and invasiveness [57][58][59] . The standard approach to the prognosis still relies on classical TNM staging, with metric factors such as tumor size and thickness, and number and size of possible lymphnode or distant metastases 31,60 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

Michálek¹,

Brychtová²,

Pink³

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for this is the formation of microenvironment in the perineural space which may contain cellular factors that act on both nerve tissue and some types of tumor tissues. Bone invasion by OSCC has major implications for tumor staging, choice of treatment, outcome and quality of life. Oral SCCs invade the mandibular or maxillary bone through an erosive, infiltrative or mixed pattern that correlates with clinical behavior. Bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. Some cytokines (e.g. TNFα and PTHrP) lead to receptor activator of NF-κB ligand (RANKL) expression or osteoprotegerin (OPG) suppression in oral SCC cells and in cancer stromal cells to induce osteoclastogenesis. Oral SCCs provide a suitable microenvironment for osteoclastogenesis to regulate the balance of RANKL and OPG. A more molecular-based clinical staging and tailor-made therapy would benefit patients with bone invasion by OSCC.

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Section: Discussionmentioning

confidence: 99%

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

Michálek¹,

Brychtová²,

Pink³

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…McGregor and MacDonald [134] recommended a resection of 5 to 10 mm of uninvolved bone around the tumor, and other researchers have suggested removal of at least 10 mm of unaffected bone in the case of macroscopic tumors with suspected bone involvement [135-137]. Intraoperative histologic evaluation of bone margins by frozen section analysis may provide critical information during mandibulectomy, but it is presently not practical in real-world settings because of the necessity of decalcification procedures before identification of the bone margin.…”

Section: Guidelines For Surgical Treatment Of Oral Cancermentioning

confidence: 99%

Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery

Joo

Cho

Koo

et al. 2019

Clin Exp Otorhinolaryngol

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Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to provide guidance on the implementation of a surgical treatment of oral cancer. MEDLINE databases were searched for articles on subjects related to “surgical management of oral cancer” published in English. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. The quality of evidence was rated with use RoBANS (Risk of Bias Assessment Tool for Nonrandomized Studies) and AMSTAR (A Measurement Tool to Assess the Methodological Quality of Systematic Reviews). Evidence-based recommendations for practice were ranked according to the American College of Physicians grading system. Additional directives are provided as expert opinions and Delphi questionnaire when insufficient evidence existed. The Committee developed 68 evidence-based recommendations in 34 categories intended to assist clinicians and patients and counselors, and health policy-makers. Proper surgical treatment selection for oral cancer, which is directed by patient- and subsite-specific factors, remains the greatest predictor of successful treatment outcomes. These guidelines are intended for use in conjunction with the individual patient’s treatment goals.

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“…Soft tissue margins are often used as surrogates to decide bony margins. Frozen section analysis of the bone marrow can alternatively be used to decide adequacy of the same [8].…”

Section: Superficial Periosteal Invasionmentioning

confidence: 99%

Management Strategies for Oral Cancer Subsites

Gupta¹,

Mahajan²,

Hore³

2019

Prevention, Detection and Management of Oral Cancer

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Oral cancers are the most common cancers in India, especially in males. This can be attributed primarily to consumption of tobacco and areca related products. Surgery is the mainstay of treatment for oral cancers with subtle subsite-specific nuances. The oral cavity starts at the mucocutaneous junction of the lips (the vermilion border) extending posteriorly to the junction of the hard and soft palate superiorly, anterior fauces laterally and the junction of the anterior two-thirds and posterior third of the tongue inferiorly. The oral cavity is lined by stratified squamous epithelium of varying degrees of keratinization. Primary tumors of the oral cavity may be derived from the mucosa, salivary glands, neurovascular tissues, bone or dental tissues. Over 90% of malignant tumors of the oral cavity are squamous cell carcinomas. There are certain basic principles of oncology, those hold true, despite the disease subsite and pathology. Stage I and II disease should be dealt with single modality treatment, whereas Stage III and IV warrant combined modality approach. Choice of modality (surgical versus non-surgical), depends on intent of treatment, chances of cure, accessibility and resectability of disease, impact on quality of life and patient's general health profile.

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Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion

Abstract: 4.

Cited by 23 publications

References 33 publications

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery

Management Strategies for Oral Cancer Subsites

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