2019
DOI: 10.1053/j.gastro.2019.03.014
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Efficacy of Budesonide vs Fluticasone for Initial Treatment of Eosinophilic Esophagitis in a Randomized Controlled Trial

Abstract: See editorial on page 14. See Covering the Cover synopsis on 1.BACKGROUND AND AIMS: Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the 2 have never been compared. We assessed whether OVB was more effective than MDI for initial treatment of patients with EoE. METHODS: In a double-blind, doubledummy trial, patients with a new diagnosis of EoE were randomly assigned to groups given 8 weeks of … Show more

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Cited by 146 publications
(103 citation statements)
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“…4,7 Steroid compounds appear to have similar antieosinophil effects, as shown in a recent trial comparing outcomes in patients treated with 1 mg of oral viscous budesonide slurry administered twice daily or 880 mg of swallowed fluticasone powder administered twice daily (histologic response of 71% and 64% after 8 weeks of treatment, respectively). 8 However, correct deposition on the epithelial surface layer is crucial to exhibit beneficial properties: viscous budesonide results in higher and longer exposure to the esophageal mucosa than does budesonide in a nebulized formulation. 9 In addition, despite steroids' efficacy in the long term, medication nonadherence appears to be an issue.…”
Section: New Steroid Formulationsmentioning
confidence: 99%
“…4,7 Steroid compounds appear to have similar antieosinophil effects, as shown in a recent trial comparing outcomes in patients treated with 1 mg of oral viscous budesonide slurry administered twice daily or 880 mg of swallowed fluticasone powder administered twice daily (histologic response of 71% and 64% after 8 weeks of treatment, respectively). 8 However, correct deposition on the epithelial surface layer is crucial to exhibit beneficial properties: viscous budesonide results in higher and longer exposure to the esophageal mucosa than does budesonide in a nebulized formulation. 9 In addition, despite steroids' efficacy in the long term, medication nonadherence appears to be an issue.…”
Section: New Steroid Formulationsmentioning
confidence: 99%
“…Serial plasma samples for fluticasone propionate PK were collected before drug administration and up to 72 hours following each dose. Plasma sample collection occurred before dose administration and at 0.5, 1, 2, 3,4,5,6,8,10,12,16,20,24,30,36,42,48,60, and 72 hours after each dose.…”
Section: Pk Samplingmentioning
confidence: 99%
“…These include proton pump inhibitors and topical corticosteroids. 1,4,5 Fluticasone propionate is a glucocorticoid with anti-inflammatory and anti-eosinophilic activity in vitro and in vivo. 6 Fluticasone propionate has very low bioavailability when swallowed, as it is only minimally absorbed from the gastrointestinal tract.…”
mentioning
confidence: 99%
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“…I rritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is a heterogeneous condition with multiple etiologies, including abnormal reactions related to foods. 1,2 Indeed, many patients with IBS commonly report adverse reactions against certain foods. 3,4 Moreover, many studies have investigated the role of food allergies in patients with IBS [5][6][7][8] ; however, the underlying mechanisms related to certain foods have not been fully elucidated.…”
mentioning
confidence: 99%