Efficacy of buffered hypertonic saline nasal irrigation in children with symptomatic allergic rhinitis: A randomized double-blind study

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

“…Consistent with results obtained by Satdhabudha and Poachanukoon [9], in the present study BHS improved the T5SS total score to a greater extent than NSS ( p < 0.001) over the treatment period. However, in contrast to the aforementioned study, a significantly greater improvement for BHS was found not only for nasal itching but also for rhinorrhoea, nasal itching, sneezing, and eye itching ( p < 0.001).…”

“…This result provides further evidence to previous data published by Satdhabudha and Poachanukoon [9] that observed a similar QoL improvement at the end of a 4-week treatment period (1 week longer) with BHS or NSS in children with AR. …”

“…Satdhabudha and Poachanukoon [9] observed a similar QoL improvement in children with AR at the end of a 4-week treatment period with BHS or NSS. The effect of BHS on nasal symptoms, QoL, and SQ in children with seasonal AR (SAR) has not yet been investigated.…”

“…Based on data from a previous study [9], a sample size of 90 measurements for each treatment group would ensure an 80% statistical power and a 5% 2-sided significance level (Epi Info, version 7.2) in detecting an expected difference of 1 in the mean T5SS total score (SD 2.4) between BHS and NSS after 2 treatment weeks. The actual sample size (per-protocol) of 15 subjects per group, yielding 315 repeated measurements per group, would provide an appropriate result.…”

“…Both normal saline solution (NSS) and buffered normal saline have been shown to be associated with good compliance and tolerance [8]. Conversely, nasal burning/irritation was reported for buffered hypertonic saline (BHS), despite its efficacy in reducing nasal symptoms in children with AR [9] and adults with rhinosinusitis [10]. …”