Efficacy of butylscopolamine for the treatment of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

Abstract

Butylscopolamine 20 mg administered i.v. after complaining CRBD during recovery reduced both the severity of CRBD and the need for rescue analgesics without adverse effects in patients undergoing urologic surgeries.

Postanaesthetic emergence agitation in adult patients after general anaesthesia for urological surgery

“…Pharmacological prevention or treatment (using gabapentin, tramadol, ketamine or butylscopolamine) decreases the incidence of CRBD in the PACU. 6,7,13,16 In a finding consistent with others, 4,5,17 postoperative pain was a risk factor for emergence agitation in the present study. Poor postoperative pain management is known to increase postoperative morbidity.…”

“…4,5 Identified risk factors for emergence agitation in adults include the use of doxapram, premedication with benzodiazepines, anaesthetic induction with etomidate, severe postoperative pain, oral cavity and otolaryngological surgery, breast surgery, abdominal surgery, extended surgical duration and presence of a tracheal tube or urinary catheter. 1,4,5 The nature of urological surgery requires the postoperative insertion of urinary catheters in the majority of patients, and such devices are associated with complications including catheterrelated bladder discomfort (CRBD; defined as voiding urgency), 6,7 which can be a risk factor for emergence agitation. 1 Little data are available regarding the risk of emergence agitation after urological surgery specifically, since the majority of studies include such patients as a subgroup in a larger surgical study population.…”

The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial

“…17 In previous studies, various agents with antimuscarinic properties, such as gabapentin, oxybutynin, tolterodine, and tramadol, were found to reduce the incidence and severity of postoperative CRBD. 1,2,[7][8][9][18][19][20] In this study, use of sevoflurane resulted in a greater reduction in the incidence of CRBD when compared with desflurane by 24%, 33%, and 26% at zero, one, and six hours after surgery, respectively. This preventive effect of sevoflurane on CRBD is similar to that of antimuscarinic agents reported in previous studies in which tolterodine and gabapentin reduced the incidence of CRBD by 19-30% until six hours postoperatively.…”

“…The incidence of CRBD has been reported to be 58-71%. 8,9,19 The relatively high incidence of CRBD in this study is related to TURBT. In patients undergoing TURBT, the bladder mucosa is electrically cauterized and a large Foley catheter is introduced postoperatively.…”

“…6 A variety of agents with antimuscarinic properties, such as ketamine, tolterodine, tramadol, and butylscopolamine, have been investigated for their ability to prevent or treat CRBD. 1,[7][8][9] Although these agents reduced the incidence and severity of CRBD, they carried additional side effects, including nausea, vomiting, sedation, and dry mouth.…”