Efficacy of captopril in experimental low renin hypertension

Heymann Nephritis-DOCA-NaCl Hypertension in the Rat

“…Unilateral nephrectomy is, how ever, also known to make rats susceptible to DOCA-NaCl treatment [4], and malignant course of such l-kidney-DOCA-NaCl hypertension has been reported using similar dosage of DOCA as used in our experiments [13], Thus, sensitivity of Heymann nephritic rats to DOCA-NaCl treatment may be due to reduction of functioning renal mass in general, without any specific connection with ne phritis itself. Indeed, a similar degree of hypertension as in Heymann nephritis-DOCA-NaCl hypertensive rats could be induced with DOCA-NaCl treatment in unilaterally nephrectomized rats [14], The pathogenesis of this "classi cal' 1-kidney-DOCA-NaCI hypertension, however, ap peared to be at least partly different from that of Heymann nephritis-DOCA-NaCl hypertension, because captopril treatment prevented the development of nephritis-DOCANaCI hypertension but was ineffective in 1-kidney-DOCANaCl hypertension [14], Moreover, we have observed that chronic N.N'-diacetyl-benzidine-induced nephropathy [15] does not sensitize to DOCA-NaCl treatment despite ap parently similar severity of proteinuria and nephrosis as in Heymann nephritic rats [ 16], Thus, aggravation of DOCA-NaCl hypertension by Heymann nephritis may reflect more specific renal changes than simply a reduction of renal mass.…”

IMMUNOLOGICAL AND ENDOCRINE FEATURES OF A NEW EXPERIMENTAL HYPERTENSION MODEL: HEYMANN NEPHRITIS‐DOCA‐NaCl HYPERTENSION

“…Despite s i m i l a r l y suppressed PRA i n b o t h models, captop r i l had a good a n t i h y p e r t e n s i v e e f f e c t i n t h e nephritis-DOCA-NaC1 model b u t was i n e f f e c t i v e i n t h e l-kidney-DOCA-NaC1 model. While t h i s r e s u l t , on t h e other hand, r i s e s i n t e r e s t i n g considerations about t h e a n t i h y p e r t e n s i v e a c t i o n o f c a p t o p r i l (13)…”