Efficacy of Carbetocin versus Oxytocin and Ergometrin in Prevention of Postpartum Hemorrhage after Cesarean Section

Abstract

Postpartum haemorrhage is defined as blood loss of 500 millilitres or more within 24 hours after a vaginal or c-section birth (WHO 2018). Hypovolemia occurs when more than 1,000mL of blood is lost in the first 24 hours after birth. A postpartum haemorrhage is defined as the loss of more than 1000 ml of blood after a caesarean operation. During and after caesarean surgery, the effectiveness and safety of intravenous carbetocin, an analogue of oxytocin, was compared against intravenous oxytocin and intramuscular ergometrine for the prevention of postpartum haemorrhage. Researchers used a randomised, prospective strategy for the study Researchers at Benha University Hospital's Obstetrics & Gynecology department worked from January 2020 to November 2021. A total of 120 people are taking part in the research. Group A received carbetocin 100g intravenously after the birth of their second child in this trial. Patients in Group B received oxytocin 10IU intravenously and ergometrine 0.02 mg intramuscularly as a combination treatment for 60 patients. Results: Estimated blood loss was significantly different between groups given carbetocin. Carbetocin, rather than oxytocin and ergometrine, is more likely to prevent atonic postpartum haemorrhage in a woman who has had several pregnancies and is undergoing a caesarean section.