Efficacy of cefminox compared with amoxicillin/clavulanic acid as a single dose for the prevention of intra-abdominal sepsis in mice intraperitoneally infected with different strains of Escherichia coli and one strain of Bacteroides fragilis

Huelves, Lorena; Gracia, Matilde; Prado, Gema del; Rodríguez-Cerrato, Violeta; Martínez-Marín, Carmina; Ponte, Carmen; Soriano, Francisco; Coronel, Pilar; Gimeno, Mercedes; Blanco, Jorge

doi:10.1016/j.ijantimicag.2006.05.022

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Cefminox has broad-spectrum antimicrobial activity and is therefore, it suitable for prophylaxis in surgical procedures, where a mixed infection may occur (17).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China

Chen

Wang

et al. 2015

Jpn J Infect Dis

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SUMMARY:To evaluate the in vitro antimicrobial activities of biapenem, arbekacin, and cefminox against different gram-negative bacterial isolates in China, a total of 100 non-duplicated Escherichia coli, 100 Acinetobacter baumannii, 100 Pseudomonas aeruginosa, and 99 Klebsiella pneumoniae isolates were collected from 6 teaching hospitals in China in 2012. The minimal inhibitory concentrations (MICs) of biapenem, arbekacin, cefminox and 13 other antibiotics were determined by the broth microdilution method. The carbapenems (biapenem, meropenem, and imipenem) exhibited high antimicrobial activity against E. coli (98z) and K. pneumoniae (95z), followed by colistin and amikacin. The MIC 50 and MIC 90 of biapenem against E. coli were 0.06 mg/L and 0.25 mg/L, respectively. For K. pneumoniae, the MIC 50 and MIC 90 of biapenem were 0.25 mg/L and 1.0 mg/L, respectively. The MIC 50 and MIC 90 of cefminox against E. coli were 1.0 mg/L and 4.0 mg/L, respectively. The resistance rates of A. baumannii to most of the antibiotics were more than 50z, except for colistin. Amikacin was the most active antibiotic against P. aeruginosa (97z), followed by colistin (93z). The MIC 50 and MIC 90 of arbekacin against P. aeruginosa were 2.0 mg/L and 8.0 mg/L, respectively. In conclusion, carbapenems, colistin, amikacin, and arbekacin exhibited high antimicrobial activities against gramnegative bacteria, except A. baumannii.

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“…Cefminox has broad-spectrum antimicrobial activity and is therefore, it suitable for prophylaxis in surgical procedures, where a mixed infection may occur (17).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China

Chen

Wang

et al. 2015

Jpn J Infect Dis

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“…51,56 Consequently, M. luteus is commonly used in antibacterial screening programs to identify compounds with potential activity against resistant Gram-positive strains. 57 Beyond its use as a model laboratory organism, M. luteus has clinical relevance as an infectious pathogen. While this bacterium was long considered nonpathogenic, recent literature recognizes M. luteus and other Microccoci as commonly misdiagnosed opportunistic pathogens that cause a variety of infections in immunocompromised patients that have been documented to be lethal in some cases.…”

Section: Further Discussion and Perspectivementioning

confidence: 99%

N–O Chemistry for Antibiotics: Discovery of N-Alkyl-N-(pyridin-2-yl)hydroxylamine Scaffolds as Selective Antibacterial Agents Using Nitroso Diels–Alder and Ene Chemistry

et al. 2011

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The discovery, syntheses, and structure-activity relationships (SAR) of a new family of heterocyclic antibacterial compounds based on N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds are described. A structurally diverse library of ~100 heterocyclic molecules generated from Lewis acid-mediated nucleophilic ring opening reactions with nitroso Diels-Alder cycloadducts and nitroso ene reactions with substituted alkenes was evaluated in whole cell antibacterial assays. Compounds containing the N-alkyl-N-(pyridin-2-yl)hydroxylamine structure demonstrated selective and potent antibacterial activity against the Gram-positive bacterium Micrococcus luteus ATCC 10240 (MIC90 = 2.0 μM or 0.41 μg/mL) and moderate activity against other Gram-positive strains including antibiotic resistant strains of Staphylococcus aureus (MRSA) and Enterococcus faecalis (VRE). A new synthetic route to the active core was developed using palladium-catalyzed Buchwald-Hartwig amination reactions of N-alkyl-O-(4-methoxybenzyl)hydroxylamines with 2-halo-pyridines that facilitated SAR studies and revealed the simplest active structural fragment. This work shows the value of using a combination of diversity-oriented synthesis (DOS) and parallel synthesis for identifying new antibacterial scaffolds.

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Efficacy of cefminox compared with amoxicillin/clavulanic acid as a single dose for the prevention of intra-abdominal sepsis in mice intraperitoneally infected with different strains of Escherichia coli and one strain of Bacteroides fragilis

Cited by 2 publications

References 8 publications

In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China

In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China

N–O Chemistry for Antibiotics: Discovery of N-Alkyl-N-(pyridin-2-yl)hydroxylamine Scaffolds as Selective Antibacterial Agents Using Nitroso Diels–Alder and Ene Chemistry

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