Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study

Chamorro-Petronacci, Cintia; Torres, Beatriz S; Guerrero-Nieves, Rocío; Pérez‐Sayáns, Mario; Fantini, M.C.A.; Silva, Luis C. Cides da; Magariños, Beatríz; Rivas-Mundina, B

doi:10.3390/ma15062266

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Combined, the DAP/TAP antibiotics allow for a very wide spectrum of action, but will have more severe side effects with higher risks of cytotoxicity and/or hindering possible dental pulp regeneration. Alone, their spectrum might prove insufficient to fully and systematically disinfect the root canal (Alghilan et al, 2017; Chamorro‐Petronacci et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

Leveque,

Guittat,

Thivichon‐Prince

et al. 2023

Int Endodontic J

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BackgroundThe clinical results following regenerative endodontic procedures (REPs) vary according to numerous parameters, including the presence of bacteria. This limitation reduces the indications for REPs and calls for the development of next generation antibacterial strategies (NGAS) providing alternatives to current antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP) and (Ca(OH)2).ObjectivesThe present scoping review aims to describe the current trends regarding the use of such strategies and highlight future perspectives.MethodsFour databases (PUBMed, Cochrane, ClinicalTrials and Science Direct) were searched until 1st May 2023.ResultsA total of 918 records were identified, 133 were screened and assessed for eligibility, and 87 articles were included. The findings show that (1) clinical studies are only available for CAS, (2) although next generation strategies are the most studied approach since 2017, they are all at the pre‐clinical stage, (3) most of the next generation strategies use galenic forms which offer cell support and colonization and which simultaneously contain antibacterial molecules as alternatives to CAS and to antibiotics in general, (4) standardization is required for future research, specifically regarding the bacterial strains studied, the use of biofilm studies and the cellular behaviour assessments.ConclusionAlthough NGAS are promising strategies to improve REPs in the context of infection, the current evidence is mostly limited to pre‐clinical studies. Further methodological improvement is required to allow relevant comparisons between studies and to reduce the time from bench to bedside.

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Section: Discussionmentioning

confidence: 99%

Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

Leveque,

Guittat,

Thivichon‐Prince

et al. 2023

Int Endodontic J

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“…E. faecalis , has been shown to be successfully eliminated by nitrofurantoin. 36 , 37 Elimination of E. faecalis in infected canal by nitrofurantoin can suggest the relief of pain experienced by the patients. Furthermore, patients who had nitrofurantoin placed into their root canals did not experience any adverse effects upon the use of this medication.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

Abbasi,

Saqib,

Maqsood

et al. 2023

SAGE Open Medicine

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Objective: The present research evaluated and compared effectiveness between nitrofurantoin and double antibiotic paste in alleviating post-operative pain in patients suffering from symptomatic irreversible pulpitis. Methods: There were 60 subjects enrolled who were allotted among three groups: Group 1 – Nitrofurantoin, Group 2 – double antibiotic paste, and Group 3 – Control. Succeeding access opening and chemo mechanical preparation, intracanal medicament was placed in the root canals. Using a numerical pain scale, pain scores were measured at the following time intervals: preoperative, 12, 24, 48, and 72 h. One-way ANOVA and post hoc statistical analysis were conducted, with a p-value of ⩽ considered as statistically significant. Results: Preoperatively, most patients experienced moderate to severe pain. The patients in groups 1 and 2 reported considerable reduction in their pain scores ( p ⩽ 0.001) on each time interval. However, patients in group 3 experienced a higher level of pain even at 72 h. No considerable distinction was found among participant’s pain scores of groups 1 and 2 ( p = 0.193). Conclusion: For effective pain-relieving, both nitrofurantoin and double antibiotic paste can be successfully used in patients suffering from symptomatic irreversible pulpitis. However, when calcium hydroxide was used, patients experience high levels of pain.

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Immobilization of Metronidazole on Mesoporous Silica Materials

et al. 2022

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Metronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug molecules to a mesoporous carrier. In this paper, we studied the fixation of MTZ molecules on mesoporous silica carriers. The drug was immobilized on two mesoporous silica materials (Syloid, SBA-15) with the use of a variety of immersion techniques and solvents. The immobilized drug was subjected to physicochemical examinations (e.g., SEM, XPS, XRD, nitrogen uptake, DSC) and dissolution studies. A significantly higher immobilization was attained on SBA-15 than on a Syloid carrier. Among the processing parameters, the type of MTZ solvent had the highest influence on immobilization. Ultrasonic agitation had a lower but still significant impact, while the concentration of MTZ in the solution made no difference. Under optimal conditions, with the application of an ethyl acetate solution, the surface coverage on SBA-15 reached as much as 91%. The immobilized MTZ exhibited a ca. 10% faster dissolution rate as compared to the pure micron-sized drug particles.

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Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study

Cited by 5 publications

References 33 publications

Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

Immobilization of Metronidazole on Mesoporous Silica Materials

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