Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy

Scoping review of rational polytherapy in patients with drug‐resistant epilepsy

“…Among RCTs ( n = 10), “refractory” epilepsy was used in seven studies 13,15,21,22,25,28,35 . Additionally, five studies also used the term “adjunctive” or “adjunctive therapy” to describe the intervention 14,16,27,29,31 .…”

“…Three studies also used the term “uncontrolled” or “not adequately controlled,” referring to seizures 23,24,26 . Among non‐RCTs ( n = 23), “refractory” epilepsy was used in 15 studies 13,15,17,18,21,22,28,30,33–35,39,40,42,43 . Two studies specifically highlighted “medically refractory epilepsy” 38 and “treatment‐resistant epilepsy.” 14 Four studies did not specifically define DRE 37,41,44,45 .…”

“…Two studies specifically referenced the ILAE definition of DRE 39,42 . Four studies highlighted if previous therapy failed to control seizures 15,21,26,38 . Two of these studies specified at least two ASMs could fail as either monotherapy or in combination 26,38 .…”

“…[23][24][25][26][27]29,31,32 Additionally, eight studies reported if seizure frequency was increased or exacerbated. 16,19,21,28,29,34 Sixteen studies addressed safety outcomes , [14][15][16][17]19,20,[24][25][26][27][28][29]31,36,38,39 while seven studies reported plasma concentrations of the study drug 13,24,26,27 and/or all ASMs taken by patients. 22,28,36 Outcomes evaluating specific ASM combinations were not part of the primary outcomes but were generally reported with or without statistical analysis.…”

“…20,23,24 Among RCTs (n = 10), "refractory" epilepsy was used in seven studies. 13,15,21,22,25,28,35 Additionally, five studies also used the term "adjunctive" or "adjunctive therapy" to describe the intervention. 14,16,27,29,31 Three studies also used the term "uncontrolled" or "not adequately controlled," referring to seizures.…”