Efficacy of coenzyme Q10 for the prevention of migraine in women: A randomized, double-blind, placebo-controlled study

Dahri, Monireh; Hashemilar, Mazyar; Asghari‐Jafarabadi, Mohammad; Tarighat‐Esfanjani, Ali

doi:10.1016/j.eujim.2017.10.003

Cited by 22 publications

(37 citation statements)

References 41 publications

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“…Reductions in the number of headache episodes, moderate or severe headaches, and migraine days by approximately 3 per month with NEC are clinically meaningful improvements and equivalent to the results of migraine prophylaxis trials with anti‐CGRP antibodies, 4–9,56 beta blockers, 57,58 topiramate, 59–62 botulinum toxin, 63,64 and nutraceuticals such as curcumin and coenzyme Q, 39,40 riboflavin, 66–68 and melatonin 69 . There were also decreases in all outcome measures in the sham treatment group consistent with the strong placebo effect reported in many migraine trials 70 .…”

Section: Discussionsupporting

confidence: 62%

“…Research has established that these processes, and in particular the generation of NO in the brain, plays a major role in migraine 17–25 . Limited data from clinical trials suggest that antioxidants such as Vit C and Vit E may improve migraine outcomes; however, further studies are required 39–43 . Our study adds to the body of clinical evidence that antioxidants might have a preventive effect in migraine.…”

Section: Discussionmentioning

confidence: 82%

“…NAc, Vit E, and Vit C were chosen as our trial drug constituents because there is clinical and basic sciences evidence of their efficacy as antioxidants and therapeutic drugs 37–47 . They have a history of safe clinical use, including as over‐the‐counter nutraceuticals, and are registered for human use by the Australian TGA.…”

Section: Discussionmentioning

confidence: 99%

“…There have only been 5 small clinical studies of antioxidants in the treatment of migraine. Two randomized controlled trials (RCTs) found the antioxidants curcumin and coenzyme Q10 decreased migraine frequency 39,40 and a single RCT reported that Vit E decreased menstrual migraines 41 . Finally, 2 uncontrolled studies reported a decrease in migraine symptoms with an antioxidant combination of pine bark extract, Vit C, and Vit E 42,43 …”

Section: Introductionmentioning

confidence: 99%

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Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

2020

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Objective To investigate the preventive effects of a combined antioxidant drug (N‐acetylcysteine, vitamin E, and vitamin C [NEC]) on migraine outcomes. Migraine is characterized by increased oxidative stress and neurogenic inflammation in the brain; therefore, antioxidants may have a migraine preventive effect. Design Randomized, double‐blind, sham‐controlled pilot study. Setting Australian community. Subjects Adults reporting 2 to 8 migraines per month for at least a year. Methods After a 1‐month baseline period, 35 subjects completed 3 months of treatment with NEC (n = 19) or sham (n = 16) capsules. The primary outcome was the difference in mean number of headaches per month between baseline and final month of the trial for NEC and sham groups; secondary outcomes are listed below. Results For NEC there was a significant decrease in mean number of headaches by 3.0 per month (P = 0.004) compared with 1.4 for sham (P = 0.073); there was no significant difference in these changes between the 2 groups (P = 0.052). Average monthly headache (P = 0.041) and migraine frequency (P = 0.018) were significantly less for NEC vs. sham. In NEC subjects, there was a significant decrease in average monthly migraine days (−3.1), moderate/severe headache days (−3.2), migraine duration, headache pain scores, and acute headache medication use. Conclusions This is the first randomized controlled trial to find that combined antioxidant therapy with NEC reduces headaches and migraines in adult migraineurs. Given the limitations of this pilot study, an adequately powered randomized controlled trial is planned to further investigate antioxidant prophylaxis in migraine.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

2020

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“…In addition, recent studies have considered CoQ10 treatment safe and possibly effective for the treatment of migraine. Besides possibly reducing the frequency, length, and severity of headaches (Shoeibi et al, 2017), its use along with other migraine prophylactic agents is well tolerated and efficacious over time (Dahri, Hashemilar, Asghari-Jafarabadi, & Tarighat-Esfanjani, 2017).…”

Section: Migrainementioning

confidence: 99%

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Arenas-Jal

Suñé-Negre

García-Montoya

2020

Comp Rev Food Sci Food Safe

142

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World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10 global causes of death, they can be prevented by risk factor reduction, early detection, and adequate treatment. Since a healthy diet along with dietary supplementation could play an important role to reduce morbidity and cut off its associated health care costs, research in the food and nutrition area is required to find solutions to global challenges affecting health. As a result of the healthy living trend, dietary supplements category is growing fast, leading to an urgent need for dietitians, physicians, and policy makers to broaden the scientific evidence on the efficacy and safety of a wide range of active ingredients. Coenzyme Q10 (CoQ10), as the third most consumed dietary supplement, and as a potential candidate for the treatment of various noncommunicable diseases that are among the global top 10 causes of death, has gained interest over years. Scientific evidence regarding mainly CoQ10 efficacy and safety, as well as formulation challenges, is addressed in this review.

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Dietary Modification and Migraine Relief

Hecht

2021

Migraine

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Efficacy of coenzyme Q10 for the prevention of migraine in women: A randomized, double-blind, placebo-controlled study

Cited by 22 publications

References 41 publications

Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Dietary Modification and Migraine Relief

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