Efficacy of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, and biomarkers of inflammation in women with polycystic ovary syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the common gynecological endocrine system diseases. It is characterized by excessive androgen, rare or anovulation, and polycystic ovary morphology. Coenzyme Q10 (CoQ10) is a fat-soluble natural vitamin, which has a continuous oxidation-reduction cycle and is an effective antioxidant that can protect ovaries from oxidative damage. This study aims to systematically summarize and analyze the scientific literatures on glucose metabolism index, lipid profiles, inflammatory factor, and sex hormone level of PCOS patients treated with CoQ10 to provide a reference basis for clinical treatment. Methods: We will retrieve the following electronic databases from the built-in until March 2021: Cochrane Library, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Clinical Trials. gov, Chinese Scientific Journal Database (VIP), and Wang-fang database. Two reviewers will independently scan the articles searched, de-duplication, filtering, quality assessment. Differences will be resolved by discussion between the 2 reviewers or by a third reviewers. All analyses were systematic to evaluate interventions based on the Cochrane handbook. Meta-analysis and/or subgroup analysis will be performed on the basis of the included studies. Discussion: This review will be to investigate the efficacy of CoQ10 supplementation on glucose metabolism, lipid profiles, and biomarkers of inflammation in women with PCOS and provide a high-quality synthesis to assess whether CoQ10 is an effective and safe intervention for PCOS. The results of the analysis will be published in a scientific journal after peer-review. Systematic review registration: INPLASY 2020100013.

Does Coenzyme Q10 Improve Ovulation and Pregnancy Rates in Clomiphene Citrate-resistant Polycystic Ovary Syndrome?

“…29 Hormonal profile was improved after Co-Q10 supplementations especially reduction in LH and testosterone levels. Similar results were obtained by Gouveia et al, 30 Izadi et al, 31 and Liu et al 32 A recent and lowering triglycerides by enhancing rapid lipolysis. These mechanisms support the wide CO-Q10 administration in women with PCOS.…”

Coenzyme Q10: A Ubiquitous Supplemental Enzyme Contributing to the Health

“…CoQ10 has a role in the regulation of blood sugar levels by improving insulin sensitivity. The administration of CoQ10 supplements can enhance glucose metabolism, leading to enhanced glycemic control among individuals with diabetes (40). Furthermore, CoQ10 functions as a potent antioxidant, thereby safeguarding the body against oxidative stress and mitigating the likelihood of experiencing diabetes problems.…”

Clinical and Biochemical Potential of Antioxidants in Treating Polycystic Ovary Syndrome

“…A study by Izadi et al 45 showed that supplementation with CoQ 10 alone or in combination with vitamin E had considerable effects on fasting plasma glucose (FPG) and homeostasis model assessment-IR (HOMA-IR) as compared to those under the placebo treatment, whereas only co-supplementation affected sex hormone-binding globulin concentrations, which decreased total serum testosterone levels. In a meta‐analysis, Liu et al 46 concluded that CoQ 10 administration can significantly reduce FPG and HOMA-IR, and effectively improve glucose and lipid metabolism, inflammation, and sex hormone levels. Refaeey et al 47 evaluated the combined ovulation induction effects of oral CoQ 10 and CC in CC-resistant PCOS patients through a prospective randomized controlled trial, and found that clinical pregnancy rate was significantly higher in the CoQ 10 group than in the control group.…”