Efficacy of colchicine in the treatment of mesenteric panniculitis in a young patient

Fasoulas, Kostas; Beltsis, Athanasios; Katsinelos, Taxiarchis; Dimou, Eleni; Arvaniti, M.; Charsoula, Anna; Gourvas, Victor; Atmatzidis, Stefanos; Chatzimavroudis, Grigoris; Katsinelos, Panagiotis

doi:10.4103/1319-3767.93825

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…The patient was subsequently treated with pentoxifylline, with substantial clinical and radiological improvements [ 42 ]. Fasoulas et al reported a case of MP in whom steroid dependence was successfully managed with colchicine without any recurrence [ 43 ]. R Mazure et al described a patient with MP refractory to surgery who achieved a good response to oral progesterone (10 mg/day for 6 months) with complete disappearance of tumor mass and clinical symptoms [ 44 ], which might be associated with their fibrinolytic characteristics [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China

Wang,

Zhao,

Cao

et al. 2024

BMC Gastroenterol

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Purpose Mesenteric panniculitis (MP) represents the uncommon, benign and chronic inflammatory disorder affecting the mesenteric adipose tissues. Its etiology, diagnosis and treatment remain unnoticed. Our report focused on shedding more lights on this condition. Patients and methods Seventeen MP patients were identified by searching the electronic medical record system in the Zhengzhou Ninth People’s Hospital using the search terms “Mesenteric panniculitis” from October 2015 to March 2023. All cases were diagnosed with MP through computed tomography (CT). Their clinical features and treatments were analyzed. Results There were altogether 17 cases enrolled for this analysis. The male to female ratio was 8:9, and the median age at diagnosis was 64 (range: 37–96) years. There were 15 patients (88.2%) showing abdominal pain to varying degrees. The proportions of symptoms of nausea, vomiting and fever were 23.5%, 23.5% and 41.2%, respectively. Neoplastic disease was present in 3 patients (17.6%). Meanwhile, 9 patients (52.9%) had gallstones, 3 (17.6%) had cholecystitis and 1 (5.9%) had gallbladder polyps. Six patients (35.3%) received antibiotics treatment only and 1 (5.9%) received oral antibiotics and prednisone. One patient (5.9%) received antibiotics followed by prednisone treatment, because the symptoms were significantly relieved after antibiotic treatment, while the disease recurred soon after, and the symptoms improved again after prednisone treatment. The abdominal pain in 9 patients (52.9%) was relieved spontaneously. Two patients (11.8%) died, including one due to respiratory failure caused by pneumonia and the other one because of pancreatic cancer with lung and liver metastases. Conclusion MP is a poorly understood chronic inflammatory disease. Patients often have abdominal pain as the main symptom, accompanied by comorbidities in the gallbladder, and the prognosis is usually good after correct diagnosis and treatment, Therefore, the present report aims to promote the awareness among clinicians of patients with non-classic abdominal symptoms, so as to avoid misdiagnosis or missed diagnosis.

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Section: Discussionmentioning

confidence: 99%

A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China

Wang,

Zhao,

Cao

et al. 2024

BMC Gastroenterol

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“… 9 In case of poor improvement of symptoms, the second line therapy to be adopted includes the association between prednisone and azathioprine 2–2.25 mg/kg daily or simply thalidomide 200 mg daily. 9 Other medical drugs used successfully, but less frequently, in different case reports are colchicine, 25 6-mercaptopurine, 26 methotrexate, 27 cyclophosphamide 28 and infliximab. 29 Surgery is reserved only in patients with complications, such as bowel obstruction.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonography-Based Management of Sclerosing Mesenteritis: From Diagnosis to Follow-Up

Sire

Imperatore

D’Armiento

et al. 2021

IMCRJ

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“…Most patients with sclerosing mesenteritis have an uneventful course and the symptoms resolve spontaneously[3]. Several therapeutic approaches with agents such as steroids, colchicine and azathioprine have been described with various therapeutic effects[16-18]. In cases of non-resolving bowel obstruction or an advanced inflammatory reaction, surgical resection of the inflamed fat may be necessary[1,12].…”

Section: Discussionmentioning

confidence: 99%

Treatment options for spontaneous and postoperative sclerosing mesenteritis

Klasen¹,

Güller²,

Muff³

et al. 2016

WJGS

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Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. The etiology is unclear; however, several potential triggers, including abdominal surgery and abdominal trauma, have been discussed. The pathology includes a benign acute or chronic inflammatory process affecting the adipose tissue of the mesenterium. Despite it being a rare disease, sclerosing mesenteritis is an important differential diagnosis in patients after abdominal surgery or patients presenting spontaneously with signs of acute inflammation and abdominal pain. We present here three cases with sclerosing mesenteritis. In two cases, sclerosing mesenteritis occurred postoperatively after abdominal surgery. One patient was treated because of abdominal pain and specific radiological signs revealing spontaneous manifestation of sclerosing mesenteritis. So far there are no distinct treatment algorithms, so the patients were treated differently, including steroids, antibiotics and watchful waiting. In addition, we reviewed the current literature on treatment options for this rare disease.

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Efficacy of colchicine in the treatment of mesenteric panniculitis in a young patient

Cited by 13 publications

References 10 publications

A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China

A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China

Ultrasonography-Based Management of Sclerosing Mesenteritis: From Diagnosis to Follow-Up

Treatment options for spontaneous and postoperative sclerosing mesenteritis

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