Efficacy of Combination of Vitamin B1, B6 and B12 in Management Of Diabetic Peripheral Neuropathy

Abstract

Aim: To determine the efcacy of combination of vitamin B1, B6 and B12 in the management of diabetic peripheral neuropathy. Methods: Patients of diabetes mellitus with diabetic peripheral neuropathy were selected from Department of Medicine, Govt. Medical College and Hospital, Bettiah, W. Champaran, Bihar and study done at Pharmacology Department of GMC, Bettiah, W. Champaran, Bihar. The duration of study was six months from March 2019 to August 2019. Patients were prescribed Tab Neurobion (vitamin B1 100mg, vitamin B6 100mg, Vitamin B12 200mcg) twice a day for a period of 4 weeks (28 days). Follow up visit was scheduled on 28th day of the initial visit. Efcacy was judged by documenting improvement in pain of at least 2 points from the baseline as assessed by numeric pain rating scale. Mean age of the patients was observed Results: 46.7±8.6 years. Out of 310 cases, 177 patients (57.0%) were male and remaining 133 patients (43.0%) were female. Duration of diabetes as follows: 83 patients (26.8%) had duration of 0-10 year, 139 patients (44.8%) had 11-20 year, 77 patients (24.8%) had 21-30 year and 11 patients (3.6%) had >30 years of duration. Combination of vitamin B1, B6 and B12 in the management of diabetic peripheral neuropathy was found to be efcacious in 271 patients (87.4%). Treatment with combination of vitamin B1, B6 and B12 Conclusion: appeared to improve pain relief among patients with diabetic peripheral neuropathy.