Efficacy of concurrent application of chlorhexidine gluconate and povidone iodine against six nosocomial pathogens

Anderson, Michael; Horn, Mary E.; Lin, Ying; Parks, Patrick J.; Peterson, Marnie L.

doi:10.1016/j.ajic.2010.06.022

Cited by 51 publications

(42 citation statements)

References 23 publications

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“…CDC, Atlanta also has recommended the use of 2% chlorhexidine glutamate as a skin disinfection before invasive procedures. 17,18 We, in our study, have reported a slight preponderance of females over males although this difference was not significant. Also, the other demographic details like age, height and weight were similar in both the groups, so had no significant difference.…”

Section: Discussioncontrasting

confidence: 37%

Comparison of chlorhexidine with povidone - iodine solution for skin disinfection in epidural and central venoues catheter insertion

Rao¹,

Rao²

2016

Int J Adv Med

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Section: Discussioncontrasting

confidence: 37%

Comparison of chlorhexidine with povidone - iodine solution for skin disinfection in epidural and central venoues catheter insertion

Rao¹,

Rao²

2016

Int J Adv Med

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“…PI is a complex of iodide and a solubilizing carrier, polyvinylpyrrolidone, which acts as a reservoir of “free” iodine, which is the active component [95]. The iodine penetrates bacterial cell membranes and inactivates key cytosolic proteins, fatty acids and nucleotides.…”

Section: Reviewmentioning

confidence: 99%

“…Chlorhexidine is a cationic biguanide that damages the outer bacterial surface layers and subsequently attacks the cytoplasmic membrane of the organism [95]. Chlorhexidine, like PI, is a broad-spectrum antimicrobial agent.…”

Section: Reviewmentioning

confidence: 99%

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Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review

Merani

Hunyor

2015

Int J Retin Vitr

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The purpose of this review is to report and summarize previously reported studies and assess many of the individual steps of the intravitreal injection procedure’s possible effect on the prevention of endophthalmitis. The pooled endophthalmitis rate from 20 large retrospective case series of anti-VEGF injections was 144/510,396 (0.028%; 1/3,544). Injections may be performed in an office-based location or in an operating room (OR) and low rates of endophthalmitis can be achieved in either location with careful attention to asepsis. Pre- or post-injection topical antibiotics have not been shown to be effective, and could select for more virulent microorganisms. Povidone-iodine prior to injection is accepted as the gold-standard antiseptic agent, but aqueous chlorhexidine may be an alternative. Antisepsis before and after gel or subconjunctival anesthetic is suggested. The preponderance of Streptococcal infections after intravitreal injection is discussed, including the possible role of aerosolization, which can be minimized by using face masks or maintaining silence. As with other invasive procedures in medicine, the use of sterile gloves, following adequate hand antisepsis, may be considered. Control of the eyelashes and lid margin is required to avoid contamination of the needle, but this can be achieved with or without a speculum. Techniques to minimize vitreous reflux have not been shown to reduce the risk of endophthalmitis. Same day bilateral injections should be performed as two separate procedures, preferably using drug from different lots, especially when using compounded drugs.

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“…This swabbing procedure was used to collect study day baseline levels and 1, 6, and 12 h after application of the preparation (postprep) nasal samples. Following collection, the swab sample was immediately immersed into a tube containing 1 ml of a neutralizer solution (NS) described previously (39). The sample tube was capped tightly and vortex mixed for ϳ1 min and then serially diluted in phosphate-buffered saline.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Skin and Nasal Povidone-Iodine Preparation against Mupirocin-Resistant Methicillin-Resistant Staphylococcus aureus and S. aureus within the Anterior Nares

Anderson

David

Scholz

et al. 2015

Antimicrob Agents Chemother

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[BN]) or left untreated. One hour posttreatment, explants were washed with phosphate-buffered saline (PBS) plus 2% mucin. One, 6, or 12 h later, bacteria were recovered and enumerated. Alternatively, following baseline sampling, human subjects applied two consecutive applications of SNP or saline to their anterior nares. One, 6, and 12 h after application of the preparation (postprep), nasal swabs were obtained, and S. aureus was enumerated. We observed that treatment of infected PM or human skin explants with SNP resulted in >2.0 log 10 CFU reduction in MRSA, regardless of mupirocin sensitivity, which was significantly different from the values for BN-and Bet-treated explants and untreated controls 1 h, 6 h, and 12 h after being washed with PBS plus mucin. Swabbing the anterior nares of human subjects with SNP significantly reduced resident S. aureus compared to saline 1, 6, and 12 h postprep. Finally, pretreatment of PM explants with SNP, followed by a mucin rinse prior to infection, completely prevented MRSA infection. We conclude that SNP may be an attractive alternative for reducing the bioburden of anterior nares prior to surgery.

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Efficacy of concurrent application of chlorhexidine gluconate and povidone iodine against six nosocomial pathogens

Cited by 51 publications

References 23 publications

Comparison of chlorhexidine with povidone - iodine solution for skin disinfection in epidural and central venoues catheter insertion

Comparison of chlorhexidine with povidone - iodine solution for skin disinfection in epidural and central venoues catheter insertion

Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review

Efficacy of Skin and Nasal Povidone-Iodine Preparation against Mupirocin-Resistant Methicillin-Resistant Staphylococcus aureus and S. aureus within the Anterior Nares

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