Efficacy of conventional whole-body 18F-FDG PET/CT in the incidental findings of parotid masses

Wang, Hui‐Chun; Zuo, Chuantao; Hua, Fang; Huang, Zhemin; Tan, Haibo; Zhao, Jun; Guan, Yihui

doi:10.1007/s12149-010-0394-6

Cited by 31 publications

(36 citation statements)

References 17 publications

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“…The largest single study evaluating the unexpected finding of focal parotid FDG uptake on PET imaging (by Wang et al) also has some significant differences as compared to our study. [17] That study consisted of 58 cases (51 with pathology follow-up) of focal FDG uptake in the parotid gland. Their results included a larger number of primary parotid tumors (74% vs. our 34%) including malignant primary parotid tumors (12% vs. 0%) and lower number of metastasis/lymphoma (5% vs. 45%).…”

Section: 1 Discussionmentioning

confidence: 99%

Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

et al. 2015

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Purpose To test whether patient's primary malignancy type and presence of FDG-avid cervical lymph node(s) are predictors of pathologic outcome of incidental focal FDG-avid parotid lesions. Basic Procedures Retrospective cohort study of pathologically proven incidental cases. Main Findings Focal parotid FDG uptake in the setting of head and neck cancer/melanoma(OR=24.6,p<0.01), lymphoma(OR=7.2,p=0.02), or FDG-avid cervical lymph node(s)(OR=3.6,p=0.07) has a higher odds of representing metastases. No malignant primary parotid tumors were incidentally discovered. Principal Conclusions In patients with head and neck cancer/melanoma, lymphoma, or FDG-avid cervical lymph node(s) there was a higher odds that focal parotid FDG uptake was a metastasis.

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Section: 1 Discussionmentioning

confidence: 99%

Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

et al. 2015

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“…FDG-PET is a critical modality for determining the localization, focal lesions, and staging of many malignant tumors, as well as for their follow-up observation. It is also essential for the clinical management of salivary tumors [4][5][6][7][8]. Like glucose, fluorodeoxyglucose (FDG) is taken up by cells via glucose transporters and phosphorylated; however, unlike glucose, FDG remains in cells after phosphorylation.…”

Section: Mechanism Of Uptakementioning

confidence: 99%

Approach to Diagnosis of Salivary Gland Disease from Nuclear Medicine Images

Nakayama¹,

Okizaki²,

Nakajima³

et al. 2019

Salivary Glands - New Approaches in Diagnostics and Treatment

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Nuclear medicine images can help in the diagnosis and assessment of some salivary disorders. 99mTcO4−, gallium-67-citrate scintigraphy will be an indication of the function of salivary gland together and it will be used for the diffuse diseases such as sialadenitis, Sjögren's syndrome, sarcoidosis, glossopharyngeal paralysis, and irradiation. It is also effective for distinguishing benign tumor legion with Warthin's tumor and others. Moreover, fluorodeoxyglucose positron emission tomography (FDG-PET) is an indispensable modality for determining the localization, focal lesions, and staging of many malignant tumors, the fluorodeoxyglucose (FDG) accumulation is visually and semiquantitatively assessed using the standardized uptake value (SUV), which is the ratio of uptake to the injected dose per unit body weight. Also for radioactive iodine therapy, attention should be paid to adverse reactions. It is important to note that acute/chronic salivary gland disorders are associated with radioiodine therapy for the treatment of postoperative thyroid cancer. Coordination among healthcare providers including nurses, radiological technologists, and doctors of all departments involved in treatment is important for achieving effective outcomes.

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“…An unexpected FDG-avid lesion (white curved arrows; SUVmax, 11) was noticed in the right parotid gland. Differential diagnoses included Sjögren sialoadenitis, 1 compensated hyperlasia, 2 benign tumors, 3 primary malignancies, 3,4 and metastases. 4,5 Because there was significant overlap of FDG avidity between malignant and benign lesions, 3,4 pathological confirmation of the parotid lesion was necessary before treatment.…”

Section: Figurementioning

confidence: 99%

“…8 The other 15% are from noncutaneous lesions of the head and neck. Metastases are seldom from infraclavicular primaries but have been reported from cancers of the lung, 4 breast, 8 gastroesophageal junction, 9 colon, 10 kidney, 3 ovary, 4 and prostate 11 as well as liposarcoma, 12 rhabdomyosarcoma, 8 and neuroblastoma. 13 Primary squamous cell carcinoma of parotid gland is rare and must be distinguished from other primary tumors of the parotid gland or metastases from extraparotid origins.…”

Section: Figurementioning

confidence: 99%

Parotid Gland Metastasis From Squamous Cell Carcinoma of Esophagus Detected by FDG PET/CT

Hsieh

Wu²,

Sun³

et al. 2012

Clinical Nuclear Medicine

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A 55-year-old man was diagnosed with squamous cell carcinoma in the middle thoracic esophagus. The FDG PET/CT revealed an incidental strong FDG-avid finding (SUVmax, 11) in the right parotid gland, which was subsequently confirmed as metastasis from the squamous cell carcinoma of esophagus via surgery. The current case adds another differential diagnosis of parotid FDG-avid lesion to the existing literature.

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Efficacy of conventional whole-body 18F-FDG PET/CT in the incidental findings of parotid masses

Abstract: Whole-body FDG-PET/CT at the time of surveying the entire body condition is helpful for detecting the asymptomatic parotid masses. Combined noncontrast CT is an essential evidence for improving the diagnostic accuracy of FDG-PET/CT for parotid masses.

Cited by 31 publications

References 17 publications

Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

Approach to Diagnosis of Salivary Gland Disease from Nuclear Medicine Images

Parotid Gland Metastasis From Squamous Cell Carcinoma of Esophagus Detected by FDG PET/CT

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