Efficacy of copper sulphate on Candida albicans on heat-polymerized acrylic resin

Huerta, Elisa; Gorup, Daisy; Manríquez, Manuel; Cruz-Choappa, Rodrigo; Vieille, Peggy; González‐Arriagada, Wilfredo Alejandro

doi:10.17126/joralres.2020.009

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In addition, the antifouling property of copper can prevent biofilm formation on acrylic surfaces by interfering with the adhesion of biofilm-associated proteins [45]. As the concentration of copper ions released from the nCu/PMMA acrylic was below the minimum inhibitory concentration (MIC) of copper for C. albicans [46], the antimicrobial effect of the nanocomposite cannot be completely explained by the copper concentration detected in saliva. Copper ions and nanoparticles that are eventually released from the nanocomposite can penetrate, migrate, accumulate, and precipitate into the complex aqueous biofilm structure [47], thereby increasing the copper concentration to antimicrobial levels.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Development of novel antimicrobial acrylic denture modified with copper nanoparticles

et al. 2023

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This study aimed to synthesize heat-cured poly(methyl methacrylate) (PMMA) acrylic formulated with copper nanoparticles (nCu) for producing dentures with antimicrobial properties and ability to prevent denture stomatitis (DS). Methods: nCu/PMMA nanocomposites were prepared through in situ formation of nCu into methyl methacrylate (MMA). The fabricated material was characterized using scanning electron microscopy, spectroscopy (energy-dispersive X-ray, attenuated total reflectance-Fourier-transform infrared, and X-ray photoelectron spectroscopy), X-ray diffraction analysis, and mechanical flexural tests (ISO 20795-1:2008). Antimicrobial activity against Candida albicans and oral bacteria was determined. MTS assay (ISO 10993-5:2009) and copper release experiments were conducted to assess cytotoxicity. In the clinical trial, participants wearing nCu/PMMA (n=25) and PMMA (n=25) dentures were compared; specifically, DS incidence and severity and Candida species proliferation were assessed for 12 months. Data were analyzed using analysis of variance with Tukey's post hoc test (α=0.05). Results: nCu/PMMA nanocomposite loaded with 0.045% nCu exhibited the maximum antimicrobial activity against C. albicans and other oral bacteria without producing cytotoxicity in the wearer. nCu/PMMA dentures retained their mechanical and aesthetic properties as well as inhibited the growth of Candida species on both denture surface and patient palate. DS incidence and severity were lower in the nCu/PMMA denture group than in the PMMA denture group. Conclusions: PMMA acrylic produced with copper nanotechnology is antimicrobial, biocompatible, and aesthetic and can reduce DS incidence. Thus, this material may act as a novel preventive alternative for oral infections associated with denture use.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Development of novel antimicrobial acrylic denture modified with copper nanoparticles

et al. 2023

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Chlorhexidine/β-cyclodextrin inclusion complexes by freeze- and spray-drying: Characterization and behavior in aqueous system

Novatski

Ribeiro

Camilo

et al. 2023

Journal of Applied Physics

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Freeze- and spray-dried inclusion complexes (ICs) of chlorhexidine (CHX) in β-cyclodextrin were characterized by Fourier transform (FT)-Raman, 1H nuclear magnetic resonance (NMR), and photoacoustic spectroscopy. The active Raman modes of CHX were simulated using the density functional theory. By considering semiempirical calculations, it was observed that the guest penetrates on the wider rim of the host in a proportion of 1:2. We observe from the FT-Raman analysis that the drying method influences the CHX:β-cyclodextrin conformational adjustment by the rearrangement of hydrophilic biguanides of the guest. The photoacoustic spectroscopy results inferred that the freeze-drying method provided a better inclusion due to a lower interaction between phenyl groups and hexamethylene of CHX. The freeze-dried IC achieved a faster dissolution pattern. These ICs provided immediate drug dissolution profiles in an aqueous medium better than a pure drug. The release profiles of freeze- and spray-dried ICs were explained by Fickian diffusion. These data support further planning and development projects of novel immediate release systems based on CHX.

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General description of some meteo-marine variables of surface waters adjacent to the Palmer Archipelago, Antarctic Peninsula, during 1979-2018 based on Era5 data

Duarte

Bolaños²,

Perdomo

2021

Bol. Investig. Mar. Costeras

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Aspatial and temporal description of meteo-marine parameters for 1979-2018 period of the marine region surrounding the Palmer Archipelago, located West of the Antarctic Peninsula (WAP), is presented. The used information was extracted from the ERA5 reanalysis. Air Temperature (Ta), Total Precipitation (TP) and Sea Surface Temperature (SST) showed a general increase over the last 40 years in the study region. The highest increase of Ta, TP and SST values were recorded north of Gerlache Strait, followed by Bismarck Strait. It was evidenced that Sea Ice Cover (SIC) has decreased mostly north of Palmer Archipelago. The existence of a local differentiation of meteo-marine conditions around the Palmer Archipelago was identified. The climatology of five reference points in the region showed more visible differences during the austral winter in Ta and SIC, these were appreciated during the austral summer in SST and a bimodal behavior was recorded in Pr. The rate of change during the 1979-2018 period for Ta was 0.011 ºC/year, for Pr it was 0.008 mm/year, for SST it was 0.004 ºC/year and for SIC it was -0.003 fraction/year.

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Efficacy of copper sulphate on Candida albicans on heat-polymerized acrylic resin

Cited by 3 publications

References 17 publications

Development of novel antimicrobial acrylic denture modified with copper nanoparticles

Development of novel antimicrobial acrylic denture modified with copper nanoparticles

Chlorhexidine/β-cyclodextrin inclusion complexes by freeze- and spray-drying: Characterization and behavior in aqueous system

General description of some meteo-marine variables of surface waters adjacent to the Palmer Archipelago, Antarctic Peninsula, during 1979-2018 based on Era5 data

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