Efficacy of Corticosteroids in the Treatment of Autoimmune Uveitis and its Effect on T Helper Cell and S100 Protein Levels in Peripheral Blood

Abstract

Short Communication Ma et al.: Corticosteroids in the Treatment of Autoimmune UveitisTo explore the efficacy of glucocorticoids in treating uveitis and their effect on T helper cell and S100 protein levels in peripheral blood. Sixty patients with uveitis were included in the uveitis group and given glucocorticoid therapy. The curative effect was evaluated after treatment. In addition, 60 healthy subjects were included in the non-uveitis group. The expression levels of T helper cell and S100 protein (S100A12, S100A8/A9) in peripheral blood of non-uveitis group and uveitis group were measured and compared, and the correlation between expression levels and clinical data was analyzed. After treatment of 60 patients with uveitis, 40 experienced complete recovery, 18 showed positive response to the treatment, while 2 cases did not respond effectively. The effective rate was 96.67 %. Before treatment, the T helper 1, T helper 17, S100A12, and S100A8/A9 levels were significantly higher in the uveitis group than in the non-uveal inflammation group (p<0.05). After treatment, T helper 1, T helper 17, S100A12, S100A8/A9 levels decreased significantly in the uveitis group (p<0.05) and approached the non-uveal inflammation group (p>0.05). The t-test showed that T helper 1, T helper 17, S100A12, S100A8/A9 levels were significantly associated with uveitis patients (p<0.05), and T helper 1, T helper 17, S100A12, S100A8/A9 levels were significantly higher in active patients. Glucocorticoid has good effect on uveitis. T helper 1, T helper 17, S100A12, S100A8/A9 and uveitis have a certain correlation, the level of T helper 1, T helper 17, S100A12, S100A8/A9 also decreased after treatment, which is a potential biomarker of uveitis.