Abstract:BackgroundNumerous individual and organizational factors can influence the spread of SARS-CoV-2 infection in Long Term Care Facilities (LTCFs). A range of outbreak control measures are still implemented in most facilities involving administrations, staff, residents and their families. This study aims to evaluate which measure could influence the transmission of SARS-CoV-2 infection among residents during the period March 2021-June 2022.MethodsWe enrolled 3,272 residents aged ≥60 years. The outbreak control mea… Show more
“…Due to the absence of effective therapies against RSV disease, prophylaxis has rapidly become the most efficient measure to reduce RSV diffusion and clinical impact in the population, especially among the most vulnerable patients such as older adults, polymorbid patients, or those living in nursing facilities. Hygiene measures, such as procedural or structural interventions, have significantly lowered respiratory virus transmission [ 70 ], but active prophylaxis remains essential and should be pursued, targeting those at higher risk of severe disease. Several clinical trials have been conducted and published that show a significant reduction in the incidence of RSV disease, especially in its most severe form.…”
Section: Discussionmentioning
confidence: 99%
“…4 ) [ 69 ]. In addition, COVID-19 spread in nursing homes and long-term care facilities was deeply reduced by procedural and structural measures, such as protected zones for family visits, entry restrictions, and COVID-19 isolation areas [ 70 ]. Fig.…”
Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significant morbidity and mortality in newborns and in the early years of life. RSV is a common infection throughout all age groups, largely undetected and underestimated in adults, with a disproportionately high impact in older individuals. RSV infection has a wide range of clinical presentations, from asymptomatic conditions to acute pneumonia and severe life-threatening respiratory distress, including exacerbations of underlying chronic conditions. Overall, the incidence of RSV infections requiring medical attention increases with age, and it is highest among persons ≥ 70 years of age. As a consequence of a combination of an aging population, immunosenescence, and the related increased burden of comorbidities, high-income countries are at risk of developing RSV epidemics. The standard of care for RSV-infected patients remains supportive, including fluids, antipyretics, and oxygen support when needed. There is an urgent need for antivirals and preventive strategies in this population, particularly in individuals at higher risk of severe outcomes following RSV infection. In this review, we describe prevention and treatment strategies for RSV illnesses, with a deep focus on the novel data on vaccination that has become available (Arexvy, GSK, and Abrysvo, Pfizer) for older adults.
“…Due to the absence of effective therapies against RSV disease, prophylaxis has rapidly become the most efficient measure to reduce RSV diffusion and clinical impact in the population, especially among the most vulnerable patients such as older adults, polymorbid patients, or those living in nursing facilities. Hygiene measures, such as procedural or structural interventions, have significantly lowered respiratory virus transmission [ 70 ], but active prophylaxis remains essential and should be pursued, targeting those at higher risk of severe disease. Several clinical trials have been conducted and published that show a significant reduction in the incidence of RSV disease, especially in its most severe form.…”
Section: Discussionmentioning
confidence: 99%
“…4 ) [ 69 ]. In addition, COVID-19 spread in nursing homes and long-term care facilities was deeply reduced by procedural and structural measures, such as protected zones for family visits, entry restrictions, and COVID-19 isolation areas [ 70 ]. Fig.…”
Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significant morbidity and mortality in newborns and in the early years of life. RSV is a common infection throughout all age groups, largely undetected and underestimated in adults, with a disproportionately high impact in older individuals. RSV infection has a wide range of clinical presentations, from asymptomatic conditions to acute pneumonia and severe life-threatening respiratory distress, including exacerbations of underlying chronic conditions. Overall, the incidence of RSV infections requiring medical attention increases with age, and it is highest among persons ≥ 70 years of age. As a consequence of a combination of an aging population, immunosenescence, and the related increased burden of comorbidities, high-income countries are at risk of developing RSV epidemics. The standard of care for RSV-infected patients remains supportive, including fluids, antipyretics, and oxygen support when needed. There is an urgent need for antivirals and preventive strategies in this population, particularly in individuals at higher risk of severe outcomes following RSV infection. In this review, we describe prevention and treatment strategies for RSV illnesses, with a deep focus on the novel data on vaccination that has become available (Arexvy, GSK, and Abrysvo, Pfizer) for older adults.
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