Efficacy of Curcumin in Combination with Intralesional Dexamethasone with Hyaluronidase in the Treatment of Oral Submucous Fibrosis: A Randomized Controlled Trial

Adhikari, Sagar; Rimal, Jyotsna; Maharjan, Iccha Kumar; Shrestha, Ashish

doi:10.31557/apjcp.2022.23.9.3125

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…These results corroborate similar clinical investigations conducted by independent research groups [116,117]. Additionally, the use of curcumin in combination with other agents has demonstrated efficacy in the treatment of oral submucous fibrosis, contributing to symptom reduction and improved treatment outcomes [118,119]. Nerkar Rajbhoj et al [118] investigated the efficacy of curcumin gel combined with Aloe vera gel alongside oral physiotherapy for managing oral submucous fibrosis (OSMF).…”

Section: Combinations Of Curcumin With Other Therapeutic Agentssupporting

confidence: 75%

“…Their findings revealed that Aloe Vera gel led to a more pronounced improvement in burning sensation scores compared to curcumin gel, possibly due to differences in their anti-inflammatory potency. Additionally, Adhikari et al [119] demonstrated the efficacy of curcumin in combination with intralesional dexamethasone and hyaluronidase for treating OSMF, reporting significant improvements in interincisal mouth opening, cheek flexibility, and tongue protrusion. The anti-inflammatory and antioxidant properties of curcumin contribute to oral health improvement.…”

Section: Combinations Of Curcumin With Other Therapeutic Agentsmentioning

confidence: 99%

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Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Yakubu,

Pandey

2024

Pharmaceutics

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Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes.

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Section: Combinations Of Curcumin With Other Therapeutic Agentssupporting

confidence: 75%

Section: Combinations Of Curcumin With Other Therapeutic Agentsmentioning

confidence: 99%

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Yakubu,

Pandey

2024

Pharmaceutics

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“…Compared to the placebo-only control group, the patients treated with curcumin showed a substantial improvement in MO, cheek flexibility, and TP. The findings suggest that the combination of curcumin, dexamethasone, and hyaluronidase may be an effective treatment for OSMF, but larger studies are needed to confirm these findings and evaluate the effectiveness of the treatment across all stages of the disease [ 90 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Curcumin in Oral Health and Diseases: A Systematic Review

Inchingolo,

Latini

et al. 2024

Antioxidants

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Curcumin (Curcumin) belongs to the polyphenol family. It is extracted by drying the root of a plant of Asian origin, belonging to the Zingiberaceae family. The best-known species is Curcumincuma Longa. Curcumin has been recognized as having great therapeutic powers since ancient times. Studies on curcumin have since confirmed its powerful antioxidant properties, preventing both the formation of free radicals and their neutralization, having anti-inflammatory, antibacterial, immunological, and neuroprotective properties, as well as being a regulator of the intestinal microbiota with beneficial effects on the clinical manifestations of metabolic syndrome. Our study aimed to highlight how all these therapeutic aspects could benefit oral health, both preventing and improving the course of pathological processes. The effect of mouthwashes, and curcumin-based gels on the regulation of bacterial plaque and in the control of gingivitis, was largely comparable to that of using 0.20% chlorhexidine, with fewer side effects. Being a highly hydrophobic substance, it has a high permeability to cross the cell membrane. Bioavailability increases when combined with liposoluble substances (e.g., olive oil) and piperine, which improves absorption. Curcumin also has a negligible degree of toxicity, making it an excellent alternative to the use of gold standard products for oral disinfection.

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Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials

Shao,

Miao,

Wang

2024

International Journal of Oral and Maxillofacial Surgery

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Efficacy of Curcumin in Combination with Intralesional Dexamethasone with Hyaluronidase in the Treatment of Oral Submucous Fibrosis: A Randomized Controlled Trial

Abstract: In a recent study conducted by Tariq et al., (2020), majority of OSF patients consumed betel nut every day, average consumption being six packets per day for nine years (Tariq et al., 2020). Betel nut chewing

Cited by 5 publications

References 23 publications

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

The Role of Curcumin in Oral Health and Diseases: A Systematic Review

Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials

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