Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections

Keiser, Jennifer; Utzinger, Jürg

doi:10.1001/jama.299.16.1937

Cited by 761 publications

(680 citation statements)

References 37 publications

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“…[40][41][42][43] A single oral dose of 400 mg of albendazole was reported to give a cure rate of 28% in a meta-analysis. 15 Generally, the reported cure rates, particularly following triple-dose treatment, were considerably higher than the one reported in this trial. Indeed, the cure rate of only 19.6% for T. trichiura as observed in our trial is much lower than that reported from a previous trial with triple-dose albendazole treatment in the same area (56%).…”

Section: Discussioncontrasting

confidence: 60%

“…The treatment of T. trichiura with a single dose of either drug results in low cure rates. 15 As both drugs are rapidly cleared from the human body and thus do not confer protection against re-infection, other control strategies, such as health education, provision of clean water and improved sanitation, and shoe wearing are required to lower infection levels permanently. Indeed, a recent systematic review and meta-analysis has shown that post-treatment re-infection is common, with prevalences of A. lumbricoides and T. trichiura returning to almost pre-treatment levels within 12 months of drug administration.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

Yap

Du²,

Fang-wei³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection (N = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of Trichuris trichiura, Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, A. lumbricoides, and T. trichiura, respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T. trichiura was considerably slower.

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Section: Discussioncontrasting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

Yap

Du²,

Fang-wei³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…This may be due to the drugs being used, as ivermectin and mebendazole have less effect over hookworms. 13,14 A similar situation was also found recently in the neighbouring country Sierra Leone. 15 The present survey is a timely addition to our understanding of the current situation of schistosomiasis and STH in Forest Guinea and illustrates the need to continue and expand the national NTD control programme to include schistosomiasis control.…”

Section: Discussionsupporting

confidence: 82%

Current status of schistosomiasis and soil-transmitted helminthiasis in Beyla and Macenta Prefectures, Forest Guinea

Hodges

Koroma

Baldé³

et al. 2011

Transactions of the Royal Society of Tropical Medicine and Hygi

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a b s t r a c tA cross-sectional survey was undertaken in children aged 9-14 years in Beyla and Macenta Prefectures, Forest Guinea. Stool samples were examined by Kato-Katz and urine samples were examined by the centrifugation method. The overall prevalence and intensity of infection was 66.2% and 462.4 eggs per gram of faeces (epg) for Schistosoma mansoni, 21.0% and 17.8 eggs per 10 ml of urine for S. haematobium, 51.2% and 507.5 epg for hookworm, 8.1% and 89.1 epg for Ascaris lumbricoides and 2.4% and 16.7 epg for Trichuris trichiura. The overall prevalence of schistosomiasis (S. mansoni and/or S. haematobium) was 70.7%. The prevalence of schistosomiasis was similar to those reported in the 1990s in the region; however, the prevalence of soil-transmitted helminths has since fallen. These findings illustrate the need for schistosomiasis control in Guinea.

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“…We urgently need specific policy options guided by further reliable evidence base to support the long-term credibility and optimal implementation of STH control programmes. For instance, the current study [1] and others have pleaded for properly conducted randomized controlled trials to address evidence gaps [6,7,5,8]. Are we absolutely clear though about which anthelminthic drugs or which combinations of those to use in future trials and thus by extension in control programs?…”

mentioning

confidence: 96%

“…Are we absolutely clear though about which anthelminthic drugs or which combinations of those to use in future trials and thus by extension in control programs? Some conclusions about the superiority of some anthelminthic drugs over others have been drawn on mainly comparisons with placebo [7]. On the other hand, treatment networks to illustrate the types and numbers of treatments compared so far (so-called "geometry" of evidence) has also been provided for major neglected tropical diseases, highlighting the study of soil transmitted helminth infections through 160 trials, including 46,887 participants [6].…”

mentioning

confidence: 99%