2022
DOI: 10.7759/cureus.28916
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Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review

Abstract: Dengue is a vector-borne disease caused by the dengue virus (DENV) and is a major health concern worldwide, particularly in regions of endemic disease. Dengue usually presents as a self-limited febrile illness. In some cases, more severe forms with hemorrhage and shock can occur, and children are especially prone to develop it. These forms can be lethal without appropriate management, and no antiviral treatment exists today. In the absence of a curative treatment for dengue, its clinical prevention remains ess… Show more

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Cited by 7 publications
(5 citation statements)
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“…For dengue, molecular surveillance also allows public officials to monitor the circulating serotypes while remaining vigilant for the emergence of novel strains or genotypes. At present, there is no approved antiviral treatment for dengue and supportive care is the only option (1719). However, two dengue vaccines have shown great promise (Takeda and Butantan vaccines) (20).…”
Section: Discussionmentioning
confidence: 99%
“…For dengue, molecular surveillance also allows public officials to monitor the circulating serotypes while remaining vigilant for the emergence of novel strains or genotypes. At present, there is no approved antiviral treatment for dengue and supportive care is the only option (1719). However, two dengue vaccines have shown great promise (Takeda and Butantan vaccines) (20).…”
Section: Discussionmentioning
confidence: 99%
“…However, in some cases, more severe forms of dengue can occur, with symptoms of hemorrhage and shock, especially in children. These variants can be fatal if not properly managed, and no effective antiviral treatment has been found to combat them [11]. According to Liao [12], individuals affected by dengue fever often present with a fever and rash.…”
Section: Epidemiological Situation Of Dengue and Its Diagnostic Chall...mentioning
confidence: 99%
“…The dengue virus heterogenicity and antibody enhancement are the main roadblocks toward developing effective vaccines against Dengue. While vaccines from reputable sources such as Sanofi, NIAID, and Takeda have recently been approved, unfortunate incidents during their implementation in children of certain countries have raised significant concerns, thus hindering the widespread adoption of these vaccines (Foucambert et al, 2022).…”
Section: Introductionmentioning
confidence: 99%