Objective: This randomized clinical trial evaluated the efficacy and safety of a blue-covarine whitening toothpaste on tooth bleaching. Subjects and methods: Seventy-five subjects with shade mean C1 or darker were randomized into three groups (n = 25): CT-conventional toothpaste, WT-whitening toothpaste, and CP10-10% carbamide peroxide. Subjects from CT and WT brushed their teeth twice/day for 2 weeks. CP10 used bleaching gel for 4 hours/night for 2 weeks. Tooth shade and CIELab parameters were measured at baseline, after the first application, 2-and 4-week. ΔE* ab and ΔE 00 were calculated. Subjects' perception about tooth color appearance, tooth sensitivity (TS), and gingival irritation (GI) were also assessed. Results: At all evaluation periods, it was not observed differences between WT and CT considering tooth shade (P > 0.7) or CIELab parameters (P > 0.3). At 2-and 4-week, ΔE* ab and ΔE 00 were higher for CP10 than WT or CT (P = 0.001). WT and CT reported major dissatisfaction with tooth color appearance than CP10 (P = 0.001). At 1-and 2-week, WT experienced GI and TS similar to CT, both lower than CP10 (P < 0.01). Conclusion: There were no significant differences in the whitening efficacy between whitening and conventional toothpastes. Neither of the dentifrices was as effective as at-home bleaching. Clinical significance: The silica-based toothpaste containing blue covarine evaluated in this study did not give significant tooth whitening benefits over 2 weeks of use. K E Y W O R D S clinical trial, tooth bleaching, tooth discolouration, toothpastes 1 | INTRODUCTION Tooth bleaching is still the most requested treatment in dental offices because it has been considered an effective and conservative way for tooth whitening. 1,2 However, the side effects frequently related to athome or in-office bleaching techniques are the gingival irritation and/or tooth sensitivity. 3,4 To promote the same benefits achieved with these techniques with lower incidence of adverse effects, several companies have developed and improved the over-the-counter (OTC) at-home bleaching products to make the treatment more accessible and to meet patients expectations. 5-8 The OTC products usually contain low levels of hydrogen peroxide (2%-6%) and include gels, rinses, gum, toothpastes, whitening strips, or paint-on films. 9-11 The action mechanisms of the OTC products are based on the bleaching of intrinsic stains using oxidizing agents to break down the organic molecules of pigments present in the teeth, and the control and removal of extrinsic stains through the abrasive agents. 12-14 Whitening toothpastes, which represent more than 50% of the OTC products, often contain optimized abrasives that may be associated to enzymes, surfactants, hydrogen peroxide (limited to about 1 wt%),