Efficacy of Desmopressin and Enuresis Alarm as First and Second Line Treatment for Primary Monosymptomatic Nocturnal Enuresis: Prospective Randomized Crossover Study

Abstract

There was no difference between desmopressin and enuresis alarm during treatment for achieving dryness, but the chance of relapse after treatment stopped was higher following desmopressin. Switching to the alternative treatment following partial or no response provided an additional benefit.

The Time of Spontaneous Resolution of Monosymptomatic Nocturnal Enuresis (MNE) Is Familial

“…There have been several articles that have investigated the efficacy and safety of the treatment options and the role of genes on MNE [4,5,6]. But there have not been any articles so far that investigate the effect of genes on the time of spontaneous resolution of MNE.…”

Transcutaneous Parasacral Electrical Neural Stimulation in Children with Primary Monosymptomatic Enuresis: A Prospective Randomized Clinical Trial

“…5e8 Of the treatments described the best long-term results are achieved with alarms, with a success rate of about 77%, 9 followed by desmopressin, with a complete response of approximately 37%. 10 Daytime incontinence in children is usually due to overactive bladder, and treatment with PTENS is an option that can achieve excellent results. 11À14 A recent systematic review showed a scarcity and lack of uniformity in the parameters of PTENS in the treatment of overactive bladder.…”

Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial

“…However, we did not study the mean bladder adaptation and urine flow pressure in the studied patients. In addition, in a study by Lee and colleagues, the combination therapy with desmopressin plus oxybutynin had a remarkable effect on speed and effectiveness of the treatment on children with nocturnal enuresis (19,20).…”