Efficacy of dexmedetomidine and propofol on shivering during mild hypothermia after cardiovascular surgery

Nihara, Y.; Kikuchi, Tsuyoshi; Sonoda, Yoshito; Nakamura, Katsumi; Yamaguchi, K.; Kakihana, Yasuyuki

doi:10.1097/00003643-201306001-00591

Cited by 2 publications

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“…A recent meta-analysis by Park et al found significant heterogeneity in the literature with respect to trial designs, interventions, and results when assessing pharmacologic anti-shivering therapies [81]. Sedatives and hypnotics including midazolam, lorazepam, diazepam, dexmetomidine, propofol, and buspirone have shiver threshold reductions ranging from 0.5 to 2.4°C when used alone and many are effective in synergistic combinations [82][83][84][85][86][87][88][89][90][91][92]. Analgesic agents such as nefopam, alfentanil, fentanyl, and meperidine have also been evaluated both as monotherapy and in combinations [93][94][95][96][97][98][99].…”

Section: Recommendationsmentioning

confidence: 99%

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society

et al. 2017

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Section: Recommendationsmentioning

confidence: 99%

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society

et al. 2017

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“…Initially, 166 trials were discarded because they were not controlled trials according to the titles, and after reviewing the abstracts, an additional 21 trials were excluded as they were not relevant to our study. We could not retrieve the full texts of three [10][11][12] of the remaining 50 papers despite attempting electronic retrieval interlibrary loan or contacting the authors. After carefully reading 47 papers, we excluded eight with no related endpoints.…”

Section: Study Selectionmentioning

confidence: 99%

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

Liu

Liang

et al. 2015

Can J Anesth/J Can Anesth

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Purpose Shivering is a frequent complication in the postoperative period. The aim of the current meta-analysis was to assess the efficacy of dexmedetomidine on postoperative shivering. with a minimum effective dose of 0.5 lgÁkg -1 (RR = 0.36; 95% CI: 0.21 to 0.60). The anti-shivering effect can be achieved both intravenously and epidurally when administered within two hours prior to the end of surgery. The efficacy of dexmedetomidine was similar to widely used anti-shivering agents, such as fentanyl, meperidine, tramadol, clonidine and so on; however, dexmedetomidine may increase the incidence of sedation, hypotension, bradycardia and dry mouth. Conclusions The present meta-analysis indicates that dexmedetomidine shows superiority over placebo, but not over other anti-shivering agents. Therefore, considering its high price and potential adverse events, dexmedetomidine may not be appropriate solely for the purpose of the prevention of postoperative shivering. RésuméObjectif Les frissons sont une complication fréquente en période postopératoire. L'objectif de cette méta-analyse était d'évaluer l'efficacité de la dexmédétomidine pour contrô ler les frissons postopératoires.

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Efficacy of dexmedetomidine and propofol on shivering during mild hypothermia after cardiovascular surgery

Cited by 2 publications

References 0 publications

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

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