Efficacy of Dexmedetomidine in Coronary Artery Bypass Graft Surgery under Cardiopulmonary Bypass: A Randomized, Double-Blind Clinical Trial

Sedighinejad, Abbas; Jouryabi, Ali Mohammadzadeh; Imantalab, Vali; Mirmansouri, Ali; Sheikhani, Nassir Nassiri; Atrkarroushan, Zahra; Biazar, Gelareh; Chaibakhsh, Yasmin

doi:10.5812/ircmj.67738

Cited by 1 publication

(2 citation statements)

References 30 publications

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“…Studies by Sedighinejad et al. 45 and Chi et al. 43 also indicated that DEX significantly decreased the cTnI level after CABG surgery.…”

Section: Discussionmentioning

confidence: 91%

“…In a study by Shen et al, 32 lower cTnI levels were observed following DEX intervention at 48 h after surgery than following the control intervention; the 48-h postsurgery cTnI levels were also lower than the 24-h postsurgery cTnI levels. Studies by Sedighinejad et al 45 and Chi et al 43 also indicated that DEX significantly decreased the cTnI level after CABG surgery. Compared with the abovementioned outcomes, the protective events against cardiac injury appeared sooner in our study than in other studies, although different surgical backgrounds and DEX usages were found in some studies.…”

Section: Discussionmentioning

confidence: 91%

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Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

Zhou

Ling

et al. 2019

J Int Med Res

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Objective This study was performed to determine the effect of dexmedetomidine (DEX) administration on myocardial damage in cardiac surgery with sevoflurane postconditioning. Methods We retrospectively examined all cardiac valve replacement surgeries from 1 April 2016 to 30 April 2017. Eligible patients were divided into two groups based on whether DEX was infused. DEX infusion was permitted only between intubation and the beginning of cardiopulmonary bypass (CPB). Sevoflurane was inhaled via the standard postconditioning procedure starting at aortic declamping. The cardiac troponin I (cTnI) level was measured at different time points. The postoperative outcomes and complications were also analyzed. Results One hundred patients were included in the study (DEX group, n = 53; non-DEX group, n = 47). Increased cTnI levels were significantly correlated with the New York Heart Association classification, CPB time, and DEX use. DEX use and the CPB time were potential independent factors contributing to changes in the cTnI level. The cTnI level at 6, 12, and 24 hours postoperatively was remarkably lower in the DEX than non-DEX group by 1.14, 7.83, and 5.86 ng/mL, respectively. Conclusions DEX decreased the cTnI level after CPB when sevoflurane postconditioning was used, especially at 6, 12, and 24 hours postoperatively.

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“…Studies by Sedighinejad et al. 45 and Chi et al. 43 also indicated that DEX significantly decreased the cTnI level after CABG surgery.…”

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

Zhou

Ling

et al. 2019

J Int Med Res

View full text Add to dashboard Cite

show abstract

Efficacy of Dexmedetomidine in Coronary Artery Bypass Graft Surgery under Cardiopulmonary Bypass: A Randomized, Double-Blind Clinical Trial

Cited by 1 publication

References 30 publications

Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

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