Efficacy of Dexpanthenol for Pediatric Post-Tonsillectomy Pain and Wound Healing

Çelebi, Şaban; Tepe, Cigdem; Yelken, Kürşat; Çelik, Osman

doi:10.1177/000348941312200710

Cited by 20 publications

(21 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The topical application of dexpanthenol is widely used to stimulate skin regeneration and promote wound healing (10,22). It is also used to manage post-tonsillectomy pain and mucosal healing (23). Although rapid wound closure was expected because of the dexpanthenol (9) found in the Oral-norm gel, in the present study, no statistically significant differences were observed in the wound width or mean wound surface area.…”

Section: Discussioncontrasting

confidence: 48%

Evaluating the Effects of a Topical Preparation Composed of Dexpanthenol, Silbiol, Undecylenic Acid and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Sezgin¹,

Çetin²,

Bulut³

et al. 2018

Balkan Med J

View full text Add to dashboard Cite

Background: Postoperative complications occur after periodontal plastic surgeries, but an ideal treatment to overcome them has not been found yet. Aims: To evaluate the effects of topically applied Oral-norm gel on the healing of excisional wounds. Study Design: Animal experiment. Methods: Excisional wounds with a diameter of 3 mm were made in the center of the palatal mucosa of 63 Sprague Dawley rats. Seven animals were sacrificed at time 0. The remaining rats were divided into two groups: a test group in which the topical Oral-norm gel was applied three times a day and a control group in which nothing was applied. Seven animals in each group were sacrificed at 3, 7, 14, and 21 days. Mean wound surface area was measured photographically, while wound healing and width were evaluated microscopically. Results: The mean wound surface area decreased significantly after 3 days in both groups (p<0.001). Between days 3 and 7, the mean wound surface area decreased from 6.62 (2.85) to 0.83 (1.62) mm 2 in the control group and 5.07 (0.88) to 1.42 (1.67) mm 2 in the test group. The wound width decreased significantly on day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had a significant increase in inflammation and vascularization on day 3 (p<0.001), with a reduction thereafter. No significant differences in macroscopic and microscopic measurements were observed between the groups at any time point (p>0.05). Conclusion: The Oral-norm gel has no positive healing effects in the palatal mucosa of rats.

show abstract

Section: Discussioncontrasting

confidence: 48%

Evaluating the Effects of a Topical Preparation Composed of Dexpanthenol, Silbiol, Undecylenic Acid and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Sezgin¹,

Çetin²,

Bulut³

et al. 2018

Balkan Med J

View full text Add to dashboard Cite

show abstract

“…In a double-blind RCT, the potential of a dexpanthenol pastille containing 100 mg dexpanthenol was evaluated to alleviate pain and to improve wound healing following tonsillectomy (69). In total, 120 pediatric patients were randomized to one of four groups (N ¼ 30 each): surgical tonsillectomy technique 1 plus dexpanthenol pastille or placebo, or surgical tonsillectomy technique 2 plus dexpanthenol pastille or placebo.…”

Section: Postoperative Usementioning

confidence: 99%

Topical use of dexpanthenol: a 70th anniversary article

Proksch

Bony

Trapp

et al. 2017

Journal of Dermatological Treatment

116

143

View full text Add to dashboard Cite

Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen TM Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol's mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field. ARTICLE HISTORY

show abstract

“…The group that took dexpanthenol suffered less pain than the placebo group, and wound healing was accelerated (26). …”

Section: Discussionmentioning

confidence: 99%

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

Madrazo-Jiménez¹,

Rodríguez-Caballero²,

Serrera-Figallo³

et al. 2016

Med Oral

View full text Add to dashboard Cite

BackgroundDespite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar.Material and MethodsA split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel.ResultsThe groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups.ConclusionsThe gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. Key words:Impacted lower third molar, postoperative wound healing, chitosan, chlorhexidine, allantoin, dexpanthenol, postoperative period.

show abstract

Efficacy of Dexpanthenol for Pediatric Post-Tonsillectomy Pain and Wound Healing

Abstract: Postoperative administration of dexpanthenol significantly accelerates the wound healing process and decreases tonsillectomy-related pain complaints.

Cited by 20 publications

References 8 publications

Evaluating the Effects of a Topical Preparation Composed of Dexpanthenol, Silbiol, Undecylenic Acid and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Evaluating the Effects of a Topical Preparation Composed of Dexpanthenol, Silbiol, Undecylenic Acid and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Topical use of dexpanthenol: a 70th anniversary article

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

Contact Info

Product

Resources

About