Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials

Kiyimba, Tonny; Yiga, Peter; Bamuwamye, Michael; Ogwok, Patrick; Schueren, Bart Van Der; Matthys, Christophe

doi:10.1016/j.advnut.2023.01.002

Cited by 27 publications

(15 citation statements)

References 80 publications

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“…The effects of cocoa astringent flavanol on the circulatory system are well studied: a meta-analysis of RCTs of adult participants at cardiometabolic risk reported between 2000 and 2021 observed a marked increase in FMD [153]. These activities on FMD of astringent anthocyanin [154] was also confirmed by the meta-analyses.…”

Section: Circulation and Polyphenolmentioning

confidence: 54%

Sensory Nutrition and Bitterness and Astringency of Polyphenols

Osakabe,

Shimizu,

Fujii

et al. 2024

Biomolecules

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Recent studies have demonstrated that the interaction of dietary constituents with taste and olfactory receptors and nociceptors expressed in the oral cavity, nasal cavity and gastrointestinal tract regulate homeostasis through activation of the neuroendocrine system. Polyphenols, of which 8000 have been identified to date, represent the greatest diversity of secondary metabolites in plants, most of which are bitter and some of them astringent. Epidemiological studies have shown that polyphenol intake contributes to maintaining and improving cardiovascular, cognitive and sensory health. However, because polyphenols have very low bioavailability, the mechanisms of their beneficial effects are unknown. In this review, we focused on the taste of polyphenols from the perspective of sensory nutrition, summarized the results of previous studies on their relationship with bioregulation and discussed their future potential.

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Section: Circulation and Polyphenolmentioning

confidence: 54%

Sensory Nutrition and Bitterness and Astringency of Polyphenols

Osakabe,

Shimizu,

Fujii

et al. 2024

Biomolecules

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“…Moreover, among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all--cause mortality (HR, 0.48; 95% CI, 0.25-0.91 and HR, 0.6; 95% CI, 0.37-0.97, respectively). A meta -analysis of 46 randomized clinical trials 94 including 2494 participants showed that the consumption of polyphenols was associated with significantly reduced systolic blood pressure (−3.69 mm Hg; 95% CI, −4.24 to −3.15 mm Hg), diastolic blood pressure (−1.44 mm Hg; 95% CI, −2.56 to −0.31 mm Hg), waist circumference (−3.04 cm; 95% CI, −7.06 to −0.98 cm), total cholesterol (−9.03 mg/dl; 95% CI, −16.46 to −1.06 mg/dl) and triglycerides (−13.43 mg/dl; 95% CI, −23.63 to −3.23 mg/dl).…”

Section: Conflict Of Interest None Declaredmentioning

confidence: 99%

Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?

Surma,

Gajos

2024

Polish Archives of Internal Medicine

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health loss, and mortality 1 diuretic, and antidiarrheic properties around the 4th century BC. For ages, until the 20th century, alcohol was widely used as a medicinal remedy, as seen in the New Testament's parable of the Good Samaritan, where wine was applied to dress wounds. 1,2 In Poland, the first vineyards appeared 1000 years ago on the Wawel Hill. Wine is a drink resulting from alcoholic fermentation, obtained exclusively from fresh grapes or their juice (so -called must), with a possible addition of permitted substances, produced in accordance with established enological processes. 1,2 It is believed that fermented drinks were consumed as far back as in the Late Neolithic period. The earliest surviving texts mentioning beer brewing and consumption date back to around 4000 BC from Mesopotamia. 1,2 Brief history of alcohol consumption Determining the exact origins of alcohol consumption is challenging. The history of wine began in Georgia 8000 years ago. Hippocrates did not recommend wine to children and pregnant women, and he expressed his philosophy regarding the beneficial effects of wine in a well -known principle: "Wine is fit for man in a wonderful way provided that it is taken with good sense by the sick as well as the healthy." Galen, who successfully developed this theory, also considered wine an important element of medical therapy. In his work De antidotis, he also mentioned many wine -based antidotes against poisons commonly used at that time. 1,2 Growing popularity of alcohol consumption was linked to its perceived medicinal properties. Aristotle noted wine's sedative, analgesic,

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“…However, other foods widely consumed are also rich in (poly)phenols including nuts, soy products, apples and pears, coffee, and citrus fruits (64) . When comparing the efficacy of (poly)phenol supplements including (poly)phenol-rich extracts v. their corresponding whole food sources, a recent meta-analysis suggests that both whole food and purified extracts can be efficacious in reducing cardiometabolic risk (65) , although more work is needed in this area.…”

Section: Effects Of (Poly)phenols On Cardiometabolic Health: Clinical...mentioning

confidence: 99%

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Rodriguez-Mateos,

Le Sayec,

Cheok

2024

Proc. Nutr. Soc.

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(Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds exert beneficial effects against cardiometabolic diseases, and this review will provide a summary of current knowledge in this area. Epidemiological and clinical data collectively suggest that intake of flavonoids reduces the risk of cardiovascular disease (CVD), with the evidence being particularly strong for the flavan-3-ol subclass. However, to provide adequate dietary recommendations, a better understanding of their estimated content in foods and intake among the general public is needed. Regarding mechanisms of action, we now know that it is unlikely that (poly)phenols act as direct antioxidants in vivo, as it was hypothesised for decades with the popularity of in vitro antioxidant capacity assays. One of the reasons is that upon ingestion, (poly)phenols are extensively metabolised into a wide array of circulating metabolites with different bioactivities than their precursors. Well-conducted in vitro and in vivo studies and human nutrigenomic analysis have revealed new molecular targets that may be underlying the health benefits of (poly)phenols, such as the nitric oxide pathway. Recently, a bi-directional relationship was established between (poly)phenols and the gut microbiota, suggesting that individual gut microbial metabolising capacity may be a key factor explaining the variability in the cardiometabolic response to (poly)phenols. Future research is needed to elucidate which are the key factors affecting such capacity, and whether it can be modulated, along with the mechanisms of action.

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Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials

Cited by 27 publications

References 80 publications

Sensory Nutrition and Bitterness and Astringency of Polyphenols

Sensory Nutrition and Bitterness and Astringency of Polyphenols

Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

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