Efficacy of Double and Triple Phototherapy in Term Newborns With Hyperbilirubinemia: The First Clinical Trial

Naderi, Salma; Safdarian, Fatemeh; Mazloomi, Davood; Bushehri, Elham; Hamidian, Reza

doi:10.1016/s1875-9572(09)60075-9

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…Similarly, Milyana NS et al2 reported that out of total of 30 cases that underwent double phototherapy, 16 were males and 14 were females. In another study of Naderi S et al 13 males and females term, neonates were 21 (52%) and 19 (48%) respectively. The likelihood of High total serum bilirubin (TSB) increases with non-Caucasian race, as and the male gender and similarly does the cephalohematoma evidence.…”

Section: Discussionmentioning

confidence: 84%

Role of Short Duration Double Phototherapy in The Treatment of Unconjugated Hyperbilirubinemia

Fatima¹,

Zaidi

Nadeem³

et al. 2021

Ann Pak Inst Med Sci

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Objective: To determine the role of short duration double phototherapy in the treatment of unconjugated hyperbilirubinemia. Materials and Methods: This prospective cases series study was conducted at pediatric department of CMH hospital at Malir Karachi. All the neonates diagnosed with unconjugated hyperbilirubinemia admitted to the neonatal ward were included. All the cases underwent short duration double phototherapy. Babies were observed for side-effects of phototherapy, like skin reaction and dehydration. Serum bilirubin was checked by bilirubinometre after 6 hourly of the treatment. Al the data was collected via study proforma. Data was analyzed by using SPSS version 20 Results: Total 74 neonates were studied, most of the neonates presented within 48-72 hours after birth. Majority of the term babies as 59.5% had history of 37-40 weeks of gestation and 28.4% had gestational age history >40 weeks. Out of all, males’ babies were 58.1% and female babies were 41.9%. Neonatal bilirubin level was significantly decreased from bassline 18.35+0.97 after 6 hours of double phototherapy as 14.66+1.18 with mean difference of 3.68+1.37 (p-value 0.001). Conclusion: Short duration double phototherapy found to be the effective, reliable and safe for skin reaction in the treatment of unconjugated hyperbilirubinemia. Key words: Hyperbilirubinemia, double phototherapy, six hours

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Section: Discussionmentioning

confidence: 84%

Role of Short Duration Double Phototherapy in The Treatment of Unconjugated Hyperbilirubinemia

Fatima¹,

Zaidi

Nadeem³

et al. 2021

Ann Pak Inst Med Sci

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“…In Table 2, we summarize the other recent RCTs (21–37), i.e., the RCTs published between 2008 up to and including 2010. These studies focussed on diagnostic aspects such as TcB measurements (21,22) as well as treatment strategies including PT (23–30), prebiotics (31) or pharmacological treatment, i.e., treatment with drugs (32–35) and Chinese herbs (36,37). It is interesting to note that increasingly these clinical trials are being conducted in non‐Western countries.…”

Section: Resultsmentioning

confidence: 99%

An evidence‐based view on hyperbilirubinaemia

Dijk

Hulzebos

2012

Acta Paediatrica

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“…Naderi's study [10] compared the benefits, complications and length of hospitalization between double and triple phototherapy in term new borns with indirect hyperbilirubinemia. He showed triple phototherapy had no particular benefit to double phototherapy and had no significant difference in overall decline rate of serum bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Declining pattern of bilirubin in the first and second six hours of intensive versus double phototherapy in neonatal jaundice

Taheri¹,

Sajjadian²,

Asadi³

et al. 2016

Pediatr Dimensions

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Background: Although phototherapy has been used in clinical practice for 50 years, there is still much debate about how the most efficacious phototherapy application can be provided.Objective: This study aimed to define the most effective hours of declining serum bilirubin in two types of phototherapy (double versus intensive phototherapy) in treatment of severe hyperbilirubinemia of neonates. Materials and methods:A total of 100 healthy full-term neonates with no hemolytic hyperbilirubinemia (total serum bilirubin between 20 to 25 mg/dl) were compared in a historically controlled study. The first group received double phototherapy (DP) (8 lamps) and the second group received intensive phototherapy (IP) (12 lamps). Results:The mean serum bilirubin decline in IP group was statistically significant in comparison with DP group in the first 6 hours of phototherapy (4.65 ± 2.02 mg/ dl versus 3.59 ± 1.86 mg/dl, P=0.008). The mean serum bilirubin decline was not statistically significant (P=0.277) in the second 6 hours of phototherapy between two groups. Conclusion:This study showed IP declined bilirubin level more than DP statistically in the first 6hoursof phototherapy. As there was no difference between DP and IP in the rate of bilirubin decline in the second 6 hours of phototherapy, DP can be used instead of IP if total bilirubin is high but under exchange transfusion level in the second 6 hours of phototherapy.

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Efficacy of Double and Triple Phototherapy in Term Newborns With Hyperbilirubinemia: The First Clinical Trial

Abstract: Triple phototherapy failed to reduce total serum bilirubin and shorten length of hospitalization more rapidly than double phototherapy.

Cited by 11 publications

References 8 publications

Role of Short Duration Double Phototherapy in The Treatment of Unconjugated Hyperbilirubinemia

Role of Short Duration Double Phototherapy in The Treatment of Unconjugated Hyperbilirubinemia

An evidence‐based view on hyperbilirubinaemia

Declining pattern of bilirubin in the first and second six hours of intensive versus double phototherapy in neonatal jaundice

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