Efficacy of enteral glutamine supplementation in patients with severe and predicted severe acute pancreatitis— A randomized controlled trial

Arutla, Madhulika; Raghunath, Manchala; Deepika, G.; Jakkampudi, Aparna; Murthy, H. V. V.; Rao, Guduru Venkat; Reddy, D. Nageshwar; Talukdar, Rupjyoti

doi:10.1007/s12664-019-00962-7

Cited by 31 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two studies included in this review were RCTs of enteral glutamine supplementation in acute pancreatitis for 7 days which investigated intestinal permeability as an outcome. 15,16 Biomarkers used to assess intestinal permeability were different in both studies. Other outcomes included in this review were incidence of infectious complication, hospital LOS, and mortality rate.…”

Section: Resultsmentioning

confidence: 90%

See 1 more Smart Citation

Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review

Setiawan

Sunardi

2021

World Nutr J

View full text Add to dashboard Cite

Background. Glutamine has been shown to improve the gut mucosal barrier. However, the evidence for benefit of enteral glutamine on intestinal permeability in acute pancreatitis (AP) is limited. Objective. To identify the effect of enteral glutamine supplementation on intestinal permeability in patients with AP. Method. A systematic search was conducted by extracting evidence from published studies on enteral glutamine supplementation in three databases (PubMed, Cochrane Central Register of Controlled Trials, and SciElo) relevant to AP from 1 January 2010 till 31 December 2020. Outcomes assessed were intestinal permeability, infectious complication, hospital length of stay, and mortality rate. Results. A total of 6 studies found by search, in which 2 human RCTs with 7 days duration of intervention with 1b-1c quality based on Criteria by Center of Evidence-Based Medicine, University of Oxford. Both studies showed the benefit of early enteral glutamine supplementation on intestinal permeability in patients with AP. Conclusions. Enteral glutamine supplementation has been shown to improve the gut mucosal barrier in AP. Despite its significant improvement in intestinal permeability, glutamine supplementation did not display a consistently positive effect on clinical outcomes.

show abstract

Section: Resultsmentioning

confidence: 90%

“…The study selection process is summarized in Figure 1. The initial systematic search identified 6 citations of which 2 potentially eligible articles 15,16 was critically appraised. We excluded 4 study for duplications and non-human study.…”

Section: Resultsmentioning

confidence: 99%

Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review

Setiawan

Sunardi

2021

World Nutr J

View full text Add to dashboard Cite

show abstract

“…There are no advantages of EN supplemented with immunonutrients [ 70 , 71 , 72 , 73 , 74 , 75 ], but parenteral administration of Gln and PUFA has been associated with a better outcome compared to the control PN with no immunonutrients [ 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ].…”

Section: Immunomodulating Nutrition (In) In Sap Patientsmentioning

confidence: 99%

Nutritional Support in Patients with Severe Acute Pancreatitis-Current Standards

Jabłońska

Mrowiec

2021

Nutrients

View full text Add to dashboard Cite

Severe acute pancreatitis (SAP) leads to numerous inflammatory and nutritional disturbances. All SAP patients are at a high nutritional risk. It has been proven that proper nutrition significantly reduces mortality rate and the incidence of the infectious complications in SAP patients. According to the literature, early (started within 24–48 h) enteral nutrition (EN) is optimal in most patients. EN protects gut barrier function because it decreases gastrointestinal dysmotility secondary to pancreatic inflammation. Currently, the role of parenteral nutrition (PN) in SAP patients is limited to patients in whom EN is not possible or contraindicated. Early versus delayed EN, nasogastric versus nasojejunal tube for EN, EN versus PN in SAP patients and the role of immunonutrition (IN) in SAP patients are discussed in this review.

show abstract

“…After removing the duplicates and screening the title and abstract, 35 articles were eligible for further assessment, of which 21 articles did not meet the inclusion criteria. Finally, 14 articles (18,19,21,22,23,24,25,26,27,28,29,30,31,32) were included in this meta-analysis. Figure 1 showet he process of literature selection.…”

Section: Study Identification and Selectionmentioning

confidence: 99%

The effect of immunonutrition in patients with acute pancreatitis: a systematic review and meta‐analysis

Zhou

Xue

Liu

et al. 2020

J Human Nutrition Diet

View full text Add to dashboard Cite

Background: The effect of immunonutrition is controversial compared to standard supplementation with respect to the management of patients with acute pancreatitis. Methods: An online literature search on four databases (PubMed, Cochrane, Embase and Web of Science) was performed to identify all of the randomised controlled trials assessing the effects of enteral or parenteral immunonutrition in acute pancreatitis. A fixed or random effects model was chosen using REV-MAN, version 5.3 (https://revman.cochrane.org). The count data were analysed using the risk ratio (RR) and 95% confidence interval (CI). Results: Five hundred and sixty-eight patients were included via our search in which 14 articles matched our criteria for enrolling the meta-analysis. Immunonutrition significantly reduced the risk of organ failure (RR = 0.42; 95% CI = 0.26-0.70, P = 0.0008), infectious complications (RR = 0.78; 95% CI = 0.62-0.99; P = 0.04) and mortality (RR = 0.37; 95% CI = 0.21-0.66; P = 0.006). Length of hospital stay was also shorter in patients who received immunonutrition (mean difference = À1.73 days; 95% CI = À2.36 to À1.10; P < 0.00001). Total interventions of patients were decreased (RR = 0.73; 95% CI = 0.55-0.97; P = 0.03). Body mass index in patients with immunonutrition was reduced more than standard nutrition (mean difference = À2.00; 95% CI = À3.96 to À0.04; P = 0.05). Conclusions: Immunonutrition support such as glutamine and x-3 fatty acids is potentially beneficial with respect to improving clinical outcomes in patients with acute pancreatitis.

show abstract

Efficacy of enteral glutamine supplementation in patients with severe and predicted severe acute pancreatitis— A randomized controlled trial

Cited by 31 publications

References 30 publications

Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review

Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review

Nutritional Support in Patients with Severe Acute Pancreatitis-Current Standards

The effect of immunonutrition in patients with acute pancreatitis: a systematic review and meta‐analysis

Contact Info

Product

Resources

About