Efficacy of erradication treatment of Helicobacter pylori infection in CagA positive and CagA negative patients

Om, Laudanno; Berli, D.; Ferrer, Javier Diaz; Fay, Martha E.; Linari, M.; Fay, Fabián; Banchio, Claudia; Cesolari, J.

doi:10.1016/s0016-5085(98)80799-3

Cited by 2 publications

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“…Forty‐seven studies of 1‐week triple therapy with omeprazole, clarithromycin and amoxycillin (OCA) were identified, from which the ITT eradication rate could be determined 14 , . 17 , 19 , 20 , 23 –65 It was unavailable from another 19 studies 66 –84 …”

Section: Resultsmentioning

confidence: 99%

“…+ A 1 g b.d 14 , . 19 , 20 , 25 , 26 , 28 , 29 , 34 , 35 , 38 , 41 , 42 , 44 –50 , 52 , 56 , 57 , 59 , 62 , 64 giving a pooled eradication rate of 82.3% ( n = 1439/1749); range 61–95% 19 , . 29 Studies have been carried out with the same doses of O + A with C 250 mg b.d 24 , .…”

Section: Resultsmentioning

confidence: 99%

“…Twice daily O 20 mg has been studied most frequently 14 , 19 , 20 , 24 –32 , 34 , 35 , 37 –39 , 41 –50 , 52 , 53 , 56 –62 , 64 , 65 with a pooled eradication rate of 82.3% ( n = 2364/2871). In two studies, 33 , 55 O 40 mg b.d.…”

Section: Resultsmentioning

confidence: 99%

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One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

Pipkin

Williamson

Wood

1998

Aliment Pharmacol Ther

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Background: One‐week triple therapies have been endorsed as the treatment regimens of choice for eradication of Helicobacter pylori infection. Those that include clarithromycin appear to be the most effective. Aim: To review reports of triple therapies that include clarithromycin. Methods: Reports were identified from the literature to May 1998. The variation between study designs prevents a formal meta‐analysis. A measure of the relative efficacies of regimens has, however, been gained by comparison and by pooling of intention‐to‐treat eradication rates. Results: One hundred and ninety‐two studies were identified which included 264 treatment arms of a 1‐week triple therapy composed of clarithromycin with amoxycillin or a nitroimidazole (metronidazole or tinidazole), and either ranitidine bismuth citrate or a proton pump inhibitor (omeprazole, lansoprazole or pantoprazole). From reports of these studies, an intention‐to‐treat H. pylori eradication rate could be determined from 210 treatment arms of 151 studies. Conclusions: There is little to choose between the efficacies of 1‐week clarithromycin‐based triple therapy eradication regimens. However, those comprising clarithromycin, a nitroimidazole and either ranitidine bismuth citrate or a high dose of omeprazole are, in general, the most effective. Against antibiotic‐resistant strains of H. pylori, regimens including ranitidine bismuth citrate may be more effective than those including a proton pump inhibitor.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

Pipkin

Williamson

Wood

1998

Aliment Pharmacol Ther

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“…In a study to evaluate the response to eradication treatment of H. pylori infection in CagA-positive and CagA-negative patients, the efficacy of the eradication treatment with triple therapy was found not to be dependent on the presence of the CagA gene (9).…”

Section: Discussionmentioning

confidence: 99%

The effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey

Saruç

Özkaya

Güçlü

et al. 2001

Braz J Med Biol Res

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If cytotoxin-associated gene A (CagA) status affects the response rates of therapy, then it may be possible to predict Helicobacter pylori eradication rates. We aimed to evaluate the response to eradication treatment of H. pylori infection in CagA-positive and CagA-negative patients. A total of 184 patients (93 males, 91 females, mean age 42.6 ± 12.8 years) with H. pylori-positive chronic gastritis were studied. Subjects underwent a gastroscopy and biopsy specimens were taken from the gastric antrum, body, and fundus. Before the eradication therapy was given all patients were tested for CagA, TNF-= and gastrin levels. They were then prescribed lansoprazole (30 mg bid), clarithromycin (500 mg bid), and amoxicillin (1.0 mg bid) for one week. On the 8th week a second endoscopy was performed and further biopsy specimens were obtained from the same sites as in the initial endoscopy. One hundred and twenty-seven patients (69.1%) were found to be CagA positive and 57 patients (30.9%) were CagA negative. The total eradication rate was 82.6%. In the CagA-positive group this rate was 87.4%, and in the CagA-negative group it was 71.9% (P = 0.019). TNF-= levels were higher in the CagA-positive than in the CagA-negative group (P = 0.001). However, gastrin levels were not different between groups (P = 0.421). Our findings revealed that CagA-negative status might be a risk factor for failure of H. pylori triple therapies. The CagA pathogenicity island gives a growth advantage to H. pylori strains and has been associated with an increase in the inflammatory response at the gastric mucosal level. These properties could make CagA-positive H. pylori strains more susceptible to antibiotics.

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Efficacy of erradication treatment of Helicobacter pylori infection in CagA positive and CagA negative patients

Cited by 2 publications

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One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

The effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey

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