Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial

Abstract

Aim: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis. Methods and results: A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups: C. zeylanicum (0.5 mg/mL), n = 18; nystatin (100,000IU/mL), n = 18. The efficacy of the products was evaluated by two parameters: (a) clinical evolution recorded by calibrated examiners (Kappa = 0.822) according to Newton's classification and (b) reduction of colonyforming units/mL. Mycological and clinical parameters were analyzed before and at 15 days after treatment. Clinical examination of the mucosa showed that C. zeylanicum (p < 0.0339) and nystatin (p < .0139) had efficacy, resulting in a reduction of signs and symptoms (Mann-Whitney test). Mycological analysis showed that C. zeylanicum caused a reduction of 61% and 33% of Candida spp., isolates oral mucosa and dentures, respectively. Candida tropicalis strains were eliminated after C. zeylanicum, in both sites. The participants reported a pleasant taste and few product-related complaints. Conclusion: C. zeylanicum EO and nystatin exhibited clinical efficacy, accordingto the Newton classification, and reducing in Candida spp. The clinical trial has been registered (Registration number: NBR-33s6 × 5, ensaiosclinicos.gov.br). K E Y W O R D Sbiological products, Cinnamomum zeylanicum, denture stomatitis, oral candidiasis INTRODUCTIONDenture stomatitis (DS) is oral candidiasis in those with removable dentures. DS is the most common type of oral lesion, affecting 75% of older adults. 1 Members of the genus

Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy

“…Prevention and management of coronavirus disease (COVID- 19) have not yet successful since no specific preventive measurement and treatment available. Therefore, searching for potential bioactive compounds from natural sources is an ongoing investigation as medicinal plants possess a tremendous antiviral compound.…”

“…Therefore, research is urgently required to find alternatives to conventional medications for eradicating IDs. Natural products based therapy could be an excellent source of antimicrobial agents that would offer symptomatic relief since they have the high potentiality to inhibit the growth of microbes in the host-defence mechanism [4], as well as they offer promising outcomes in the scientific investigations [15][16][17][18][19][20]. Additionally, it would reduce unnecessary antibiotic prescription; therefore, the chances of antibiotic-resistance would be reduced.…”

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

“…Particularly, the effects of mouthwash and spray containing cinnamon essential oil on Candida spp have been analyzed. A reduction of 61% and 33% of fungi isolates from oral mucosa and dentures, respectively, was noted, whereas the participants of the study reported a pleasant taste and only a few product-related complaints [ 79 ].…”

Biomaterials for the Prevention of Oral Candidiasis Development

“…The antifungal properties of cinnamon are more pronounced than its antibacterial activity, indicating potential use in candidiasis treatments either as the main or a complementary agent [127][128][129][130]. De Araujo et al [131] analyzed the efficacy of mouthwash and spray containing essential oil of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis. A mycological analysis demonstrated a reduction of 61% and 33% of Candida spp., isolated from oral mucosa and dentures, respectively.…”