Efficacy of ethanol as a discriminative stimulus in ethanol-preferring and ethanol-nonpreferring rats

Jl, York

doi:10.1007/bf01944692

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1979

2016

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Cited by 11 publications

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Drug Discrimination: Practical Considerations

2011

Drug Discrimination

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Drug Discrimination: Practical Considerations

2011

Drug Discrimination

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Discriminative Stimulus Effects of Abused Inhalants

Shelton

2016

The Behavioral Neuroscience of Drug Discrimination

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Inhalants are a loosely organized category of abused compounds defined entirely by their common route of administration. Inhalants include volatile solvents, fuels, volatile anesthetics, gasses, and liquefied refrigerants, among others. They are ubiquitous in modern society as ingredients in a wide variety of household, commercial, and medical products. Persons of all ages abuse inhalants but the highest prevalence of abuse is in younger adolescents. Although inhalants have been shown to act upon a host of neurotransmitter receptors, the stimulus effects of the few inhalants which have been trained or tested in drug discrimination procedures suggest that their discriminative stimulus properties are mediated by a few key neurotransmitter receptor systems. Abused volatile solvent inhalants have stimulus effects that are similar to a select group of GABA positive modulators comprised of benzodiazepines and barbiturates. In contrast the stimulus effects of nitrous oxide gas appear to be at least partially mediated by uncompetitive antagonism of NMDA receptors. Finally, volatile anesthetic inhalants have stimulus effects in common with both GABA positive modulators as well as competitive NMDA antagonists. In addition to a review of the pharmacology underlying the stimulus effects of inhalants, the chapter also discusses the scientific value of utilizing drug discrimination as a means of functionally grouping inhalants according to their abuse-related pharmacological properties.

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Behavioral Manifestations of Ethanol Intoxication and Physical Dependence

Barry¹

1979

Biochemistry and Pharmacology of Ethanol

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Efficacy of ethanol as a discriminative stimulus in ethanol-preferring and ethanol-nonpreferring rats

Cited by 11 publications

References 8 publications

Drug Discrimination: Practical Considerations

Drug Discrimination: Practical Considerations

Discriminative Stimulus Effects of Abused Inhalants

Behavioral Manifestations of Ethanol Intoxication and Physical Dependence

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