Efficacy of EUS-guided celiac plexus neurolysis compared with medication alone for unresectable pancreatic cancer in the oxycodone/fentanyl era: a prospective randomized control study

Kanno, Yoshihide; Koshita, Shinsuke; Masu, Kaori; Ogawa, Takahisa; Kusunose, Hiroaki; Murabayashi, Toji; Sakai, Toshitaka; Kozakai, Fumisato; Ito, Kei

doi:10.1016/j.gie.2020.01.011

Cited by 41 publications

(63 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An initial search identified 176 articles, out of which 142 studies were initially excluded (studies that involved chronic pancreatitis patients and studies presented as abstracts in conferences). Thirty-four relevant studies were selected and reviewed in detail, of which 18 studies that utilized celiac plexus block technique were excluded and only 16 studies met the final inclusion criteria [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Figure 1 shows the search results.…”

Section: Resultsmentioning

confidence: 99%

EUS-guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta-analysis and systematic review

Asif

Walayat

Bechtold

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

EUS-guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta-analysis and systematic review

Asif

Walayat

Bechtold

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

show abstract

“…In order to compare medications using oxycodone and/or fentanyl with and without EUS-CPN, Kanno et al 21 recently evaluated the efficacy of EUS-CPN for pancreatic cancer pain. As a result, EUS-CPN did not improve pain, quality of life (QOL), or opioid consumption compared to patients who did not undergo EUS-CPN or receive oxycodone and/or fentanyl.…”

Section: Efficacy and Prognostic Factors Following Treatmentmentioning

confidence: 99%

Recent topics on endoscopic ultrasonography-guided celiac plexus neurolysis

Yasuda

Hanaoka

Takahashi

et al. 2020

Int J Gastrointest Interv

View full text Add to dashboard Cite

Endoscopic ultrasonography-guided celiac plexus neurolysis (EUS-CPN) is a widely practiced technique. Three sets of guidelines have recently been published and this procedure has become a major EUS technique. However, there are still several unanswered questions. The purpose of this manuscript is to review the recent literature pertaining to EUS-CPN. Currently, the main indication of EUS-CPN is pancreatic cancer pain. It is also performed for patients with chronic pancreatitis, but the indication is controversial due to its limited efficacy and a high incidence of infectious complications. Various techniques, such as central and bilateral EUS-CPN, and EUS-guided direct celiac ganglia neurolysis (EUS-CGN) have been performed. However, the efficacies of these techniques remain controversial. Complications related to the procedures are generally not serious, but major adverse events, such as paraplegia and ischemic complications, have been reported. The impacts of EUS-CPN on survival have also been evaluated. Although increased survival was expected via improvements in the quality of life, data suggests that EUS-CPN related procedures, especially EUS-CGN, might reduce the survival time. However, precise mechanisms have not been elucidated. In addition to conventional techniques, new techniques, such as EUS-guided celiac ganglion radiofrequency ablation (EUS-RFA) and the use of highly viscous phenol-glycerol, dexmedetomidine, and contrast-enhanced agents, have been introduced. However, these techniques are still in experimental stages. Additional studies need to be conducted to address these gaps in the literature.

show abstract

“…Kanno et al 26 did a prospective randomized trial comparing EUS-guided neurolysis versus medications alone in unresectable pancreatic cancer in the oxycodone/fentanyl era. The study comprised two arms.…”

Section: Recent Updatesmentioning

confidence: 99%

Untitled

2020

Journal of Digestive Endoscopy

View full text Add to dashboard Cite

Endoscopic ultrasound (EUS)-guided celiac plexus intervention comprises EUS-guided celiac plexus block (EUS-CPB) and EUS-guided celiac plexus neurolysis (EUS-CPN). EUS-CPB and EUS-CPN are one of the used methods of pain management in patients of pancreatic cancer and chronic pancreatitis, respectively, along with medical therapy. Both the procedures are associated with minimal complications and improves quality of life. The role of EUS-guided celiac plexus intervention is increasing in gall bladder carcinoma for pain control.

show abstract

Efficacy of EUS-guided celiac plexus neurolysis compared with medication alone for unresectable pancreatic cancer in the oxycodone/fentanyl era: a prospective randomized control study

Cited by 41 publications

References 33 publications

EUS-guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta-analysis and systematic review

EUS-guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta-analysis and systematic review

Recent topics on endoscopic ultrasonography-guided celiac plexus neurolysis

Untitled

Contact Info

Product

Resources

About