Efficacy of Fasting and Calorie Restriction (FCR) on mood and depression among ageing men

Hussin, Norlela Mohd; Shahar, Suzana; Teng, Nur Islami Mohd Fahmi; Ngah, W. Z. Wan; Das, Sai Krupa

doi:10.1007/s12603-013-0344-9

Cited by 81 publications

(80 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among participants of the Chicago Health and Aging Project, for instance, researchers reported an energy intake of 1,500 ± 573 kcal in the lowest tertile of Mediterranean Diet Score (MedDietScore) and 1,945 ± 578 kcal in the upper tertile, which had lower annual depression rates (Skarupski, et al, 2013). A 3-month clinical trial testing the effects of fasting and moderate calorie restriction in 32 healthy Malay men, aged 50 to 70 years, found no significant differences in depression scores (Hussin, Shahar, Teng, Ngah, & Das, 2013). The higher overall energy intakes in our study may reflect a higher energy expenditure, possibly due to higher physical activity potentially due to better health (J. J.…”

Section: Discussionmentioning

confidence: 51%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

Depression is associated with decreased quality of life and high mortality risk at all ages and, despite having lower prevalence in community-dwelling seniors compared to other stages of the life span or institutionalized elderly, it negatively affects seniors' health outcomes. Most evidence linking late-life depression, defined as first onset after 65 years of age, with dietary factors comes from cross-sectional studies, which cannot provide information on whether declines in diet were a consequence of depression-the reverse causality hypothesis. The Quebec Longitudinal Study on Nutrition and Aging (NuAge) provides an ideal setting to explore such a relationship among a healthy, community-dwelling elderly population. Diet is hypothesized to be a factor associated with depression. Some longitudinal evidence from studies with middle-aged adults suggests that dietary patterns such as the Mediterranean or patterns deemed "healthy" are protective against depression, while "western" and "unhealthy" patterns are risk factors for the disease. B-vitamins are important cofactors in neurotransmitter synthesis and in the enzymes of the one-carbon metabolism, which has been hypothesized to have an aetiological role in depression through its neurotoxic derivates, such as homocysteine. Nonetheless, it is still largely unknown how depression affects nutrient intake in the elderly population, raising the question of the directionality of the association. Therefore, ii the three objectives of this thesis were to explore the longitudinal associations of i) dietary patterns and macronutrient intake and of ii) B6, B12 and folate intakes with the incidence of depression in late life; and iii) to investigate whether depression significantly affects short-term nutrient intakes (reverse causality effect) in comparison to intakes among non-depressed seniors.Data for this study have been obtained from the NuAge cohort, a 4-y longitudinal study of 1,793 community-dwelling men and women aged 68 to 82 years at baseline. The main outcome is incidence of depression as defined by scores in the 30-item Geriatric Depression Scale ≥11 and or antidepressant medication use over the three years of follow-up. Participants were free of depression at the study's baseline through the exclusion of those with GDS scores ≥11 or antidepressant use at the time of the recruitment. Individuals with invalid or missing dietary information were also excluded. Dietary patterns were created through principal component analysis on amount (grams) of food items consumed in each of the 32 predefined food categories. Sex-specific tertiles of intake were created from the mean of three non-consecutive 24h-recalls. Multiple logistic regression models were adjusted for several demographic, health, and social confounders. For the study of the reverse causality hypothesis, we conducted a case-control nested within the NuAge cohort. Participants free of iii depression at baseline who developed depression at some point of follow-up were matched by age group and sex with...

show abstract

Section: Discussionmentioning

confidence: 51%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

“…The second randomized controlled trial of fasting was reported in 3 articles using the primary endpoints of "mood states and depression status" (34), "metabolic parameters and DNA damage" (35), and "mood and quality of life" (33). One of these articles was published before full enrollment in the trial (33), used similar outcomes as one of the other articles (34), and will not be discussed.…”

Section: Evidence Of a Fasting Benefit For Humans Based On Surrogate mentioning

confidence: 99%

“…Overall mood-including components from tension, anger, and confusion-was improved by fasting in a study of 32 subjects during 12 wk of the intervention phase. Unfortunately, correction for the 7 hypothesis tests of measures of mood was not done and would result in no finding being statistically significant (34). From the same 12-wk trial but in another article, blood pressure, total cholesterol, LDL cholesterol, weight, fat mass, and other factors-including DNA damage measures-were changed by fasting (35).…”

Section: Evidence Of a Fasting Benefit For Humans Based On Surrogate mentioning

confidence: 99%

“…From the same 12-wk trial but in another article, blood pressure, total cholesterol, LDL cholesterol, weight, fat mass, and other factors-including DNA damage measures-were changed by fasting (35). As before, no primary hypothesis was specified, and no correction for multiple comparisons was made in what must be considered a subsequent analysis of the prior study (34). None of these reports evaluated safety outcomes for the trial (33)(34)(35).…”

Section: Evidence Of a Fasting Benefit For Humans Based On Surrogate mentioning

confidence: 99%

See 1 more Smart Citation

Health effects of intermittent fasting: hormesis or harm? A systematic review

Horne

Muhlestein

Anderson

2015

The American Journal of Clinical Nutrition

207

117

View full text Add to dashboard Cite

show abstract

“…Mood improvement that occurs during these first few days of fasting could be a direct consequence of this activation. In clinical studies, fasting is frequently accompanied by increased vigilance and mood-enhancement, a subjective feeling of well-being, and sometimes even a feeling of euphoria [53,112,113,114,115,116]. …”

Section: Clinical Effects Of Fastingmentioning

confidence: 99%

Fasting Therapy for Treating and Preventing Disease - Current State of Evidence

Michalsen

2013

Complement Med Res

114

View full text Add to dashboard Cite

Periods of deliberate fasting with restriction of solid food intake are practiced worldwide, mostly based on traditional, cultural or religious reasons. There is large empirical and observational evidence that medically supervised modified fasting (fasting cure, 200-500 kcal nutritional intake per day) with periods of 7-21 days is efficacious in the treatment of rheumatic diseases, chronic pain syndromes, hypertension, and metabolic syndrome. The beneficial effects of fasting followed by vegetarian diet in rheumatoid arthritis are confirmed by randomized controlled trials. Further beneficial effects of fasting are supported by observational data and abundant evidence from experimental research which found caloric restriction and intermittent fasting being associated with deceleration or prevention of most chronic degenerative and chronic inflammatory diseases. Intermittent fasting may also be useful as an accompanying treatment during chemotherapy of cancer. A further beneficial effect of fasting relates to improvements in sustainable lifestyle modification and adoption of a healthy diet, possibly mediated by fasting-induced mood enhancement. Various identified mechanisms of fasting point to its potential health-promoting effects, e.g., fasting-induced neuroendocrine activation and hormetic stress response, increased production of neurotrophic factors, reduced mitochondrial oxidative stress, general decrease of signals associated with aging, and promotion of autophagy. Fasting therapy might contribute to the prevention and treatment of chronic diseases and should be further evaluated in controlled clinical trials and observational studies.

show abstract

Efficacy of Fasting and Calorie Restriction (FCR) on mood and depression among ageing men

Abstract: Our findings show that a FCR dietary regime is effective in improving mood states and nutritional status among ageing men.

Cited by 81 publications

References 20 publications

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

Health effects of intermittent fasting: hormesis or harm? A systematic review

Fasting Therapy for Treating and Preventing Disease - Current State of Evidence

Contact Info

Product

Resources

About