Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Godara, R.; Sharma, Ruchi; Sodhi, Simrinder Singh

doi:10.1007/s12639-011-0052-5

Cited by 13 publications

(13 citation statements)

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“…Knowing the history of previous exposure to benzimidazole or LEV, the results are not unexpected. However, finding IVM resistance against GIN is found to be alarming as this drug was found to effective in the given geographical areas in all previous studies (Gill 1996;Ram et al 2007;Godara et al 2011). Similar resistance of GIN against IVM in sheep of the same geographical was obtained by one of the author of this paper (Makvana & Singh 2009), which further emphasizes that there is emergence of resistance against this drug in the area.…”

Section: Resultssupporting

confidence: 78%

“…The odds ratio for relative risk of getting H. contortus egg was 0.133 (0.07-25; 95% CI) after treatment with IVM as compared to control. In other studies, benzimidazole-resistant H. contortus (Jeyathilakan et al 2003) and multiple anthelmintic resistances in H. contortus against benzimidazole and LEV (Godara et al 2011;Jaiswal et al 2013;Manikkavasagan et al 2013) were documented. However, faecal cultures from IVM-treated group revealed significantly high (69%) number of Trichostrongylus species, which was having meagre (5%) presence before treatment.…”

Section: Resultsmentioning

confidence: 90%

“…Several cases of benzimidazole group drug resistance have been reported in goats (Chartier et al 2001;Jaiswal et al 2013). Levamisole has also been reported to be losing its efficacy in caprine species during recent years particularly in Indian sub-continent (Godara et al 2011;Manikkavasagan et al 2013;Jaiswal et al 2013). Suspicions of IVM resistance, however, are less commonly documented in India and world (Paraud et al 2010;Jaiswal et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Gelot

Singh

Shyma

et al. 2015

Journal of Applied Animal Research

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Faecal samples from 140 adult goats were collected and positive samples were examined quantitatively; goats having at least 500 eggs/g of faeces were selected and randomly divided into four groups. Faecal egg count reduction test was used to detect the efficacy of albendazole (ALB), levamisole (LEV) and ivermectin (IVM) in goats naturally infected with gastrointestinal nematodes in a semi-organized farm located in semi-arid region of Gujarat, India. ALB, LEV and IVM reduced faecal egg counts on 14th day post-treatment varied from 53% to 76%, revealing presence of resistance of worms to all these drugs. Finding IVM resistance in gastrointestinal nematodes is found to be alarming. Pre-treatment faecal culture of all the groups collectively revealed Haemonchus spp. as the predominant parasite again post-treatment faecal cultures further emphasize the pre-dominance of H. contortus in ALB-and LEV-treated groups. However, faecal cultures from IVM-treated group revealed predominance of Trichostrongylus species which were scarce in pre-treatment group. Study further reveals that only ALB was found to be effective against Oesophagostomum spp., and most of the gastrointestinal nematodes were found to have some degree of resistance against rest of the other drugs used in goats.

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Section: Resultssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Gelot

Singh

Shyma

et al. 2015

Journal of Applied Animal Research

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“…Goats infected with internal parasites show rough dull-coat, weakness, diarrhea, apathy, tail rubbing, signs of hypoproteinaemia, loss of appetite, and weight loss (Risso et al, 2015;Kaplan, 2016). The incidence of trichostrongylosis in sheep and goats was reported by Godara et al (2011) and Jaiswal et al (2013). The anthelmintic activity and therapeutic efficacy of fenbendazole, levamisole and ivermactin have been studied in goats (Godara et al, 2011, Jaiswal et al, 2013, Das et al, 2016.…”

Section: Study On Clinico-haematol-biochemical Alterations In Goatsmentioning

confidence: 84%

Study on Clinico-Haematol-Biochemical Alterations in Goats Suffering from Trichostrongylosis in Anand District of Gujarat

Rajpura

Mandali

Rao

et al. 2019

IJVSBT

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This cross-sectional study was aimed at determining the effect of trichostrongylosis on clinical, hematological, and biochemical parameters in goats. The study included eight healthy control goats and 48 naturally infected goats from the Anand district of Gujarat. The cases having a history of diarrhea, anorexia, weakness, dullness, loss of weight, and not dewormed were selected. Fecal samples of infected goats were examined by direct smear method for the presence of Trichostrongylus spp. eggs and the infection was confirmed by quantitative evaluation and coproculture of the samples for the identification of larvae. The result indicated that the infected goats have significantly elevated rectal temperature, pulse rate, and respiration rate along with diarrhea, dullness, depression, emaciation, and loss of condition. Moreover, there was a significant decrease in the mean Hb, TEC, PCV, lymphocyes, as well as serum total protein, calcium and phosphorus, and a significant increase in TLC, neutrophils, eosinophils, ALT, AST and ALP in infected goats.

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“…However, the age group ≥12 had the highest (71.43%) infection of Trichostrongylid nematode infection among sheep followed by age group 8-9 (69.69%), while the age group 10-11 had the least infection (67.5%) (P=0.934). This high prevalence could be as a result of increased grazing habits, climate, nutritional deficiency, pasture management, hygiene, number of infective larvae and eggs in the environment (Godara et al, 2011). …”

Section: Resultsmentioning

confidence: 99%

Prevalence of trichostrongylid nematode in sheeps in Benin City, Edo state, Nigeria

Omoruyi¹,

Aiguobasinmwin²,

Shehu³

2017

Bayero J. Pure App. Sci.

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Parasitism of Trichostrongylid nematode is a world-wide problem for both small and large scale farmers and is a great threat to the livestock industry and also a major constraint to the wellbeing and productive performance of ruminant animals. This study was carried out to determine the effect of Trichostrongylid nematode in sheep. The study was carried out in Aduwawa, Ugbiyokho, Oluku and Airport road in Edo State in 2015. A total of one hundred and fifty (150) sheep were examined for the present of gastrointestinal parasite. Sedimentation technique was used in examining the faecal sample for the presence of the GIT pararsites. The prevalence of eggs and larvae of H. contortus were 71.3% and 15.3%, Trichostrongylus species were 61.3% and 7.3%, O. ostertagii were 42.7% and 6.7% respectively. Among 150 faecal sample examined, 103 (68.67%) were found positive for Trichostrongylid infection. Grazing time, consistency of faeces and weight are factors having significant impact on the infection in sheep. Sheep that graze in the evening had the highest prevalence (82%), faecal samples that were unformed had the highest prevalence (85.71%) and sheep with weight range of 10kg-30kg showed the highest prevalence (97.96%). Chi-Square Test used to determine the relationships between age and location, had no significant impact on the prevalence of infection. These factors need to be considered in the control of trichostrongylid nematode infection but more emphasis should be given to improvement of hygiene, regular de-worming and frequent diagnosis of trichostrongylid nematode and management of infected animals.

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Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Cited by 13 publications

References 5 publications

Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Study on Clinico-Haematol-Biochemical Alterations in Goats Suffering from Trichostrongylosis in Anand District of Gujarat

Prevalence of trichostrongylid nematode in sheeps in Benin City, Edo state, Nigeria

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