Efficacy of fentanyl, dexmedetomidine or lidocaine in attenuating the hemodynamic response to rigid bronchoscopy

Abstract

Bronchoscopy entails significant manipulation of the upper and lower respiratory tracts with marked hemodynamic response and therefore represents a potentially greater hazard to safe anesthesia.There have been many attempts to attenuate these adverse effects. Dexmedetomidine is highly selective, short-acting central alpha 2 agonist. It has increasingly gained popularity among anesthesiologists as adjuvant to general and regional anesthesia techniques. This study was conducted to compare the efficacy of administratingfentanyl, dexmedetomidine or lidocaine on control of hemodynamic changes to rigid bronchoscopy in pediatric patients. Ninety ASA I-II children aged 2-12 year were randomly assigned to 3 groups: fentanyl (F), dexmedetomidine (D) and lidocaine (Z). HR, SAP, MAP, DAP and SPO2 were measured and recorded. Results revealed that patients in the D group showed minimal changes in hemodynamic parameters in response to the procedure of rigid bronchoscopy. We concluded that dexmedetomidine can be used safely and effectively to attenuate the hemodynamic responses to rigid bronchoscopy in pediatric patients.