Efficacy of ferric carboxy maltose in treatment of iron deficiency/iron deficiency anaemia during pregnancy

Abstract

Introduction: To evaluate the efficacy of ferric carboxy maltose (FCM) in the treatment of iron deficiency/iron deficiency anaemia (ID/IDA) during pregnancy.Material and methods: Pregnant women ≥ 20 years old diagnosed with ID (serum ferritin < 15 μg/l) and moderate IDA were included in this study for correction of their ID/IDA. The participants received an FCM infusion for correction of their ID/IDA. The pre-treatment ferritin, haemoglobin (Hb), and red blood cell (RBC) indices were compared with the 6-and 12-week post-treatment values to evaluate the efficacy of FCM in the treatment of ID/IDA during pregnancy.Results: The pre-treatment ferritin and Hb significantly increased from 10.3 ±2.3 μg/l and 7.99 ±0.6 g/dl, respectively, to 139.5 ±1.9 and 14.04 ±0.45, respectively, 6-weeks after FCM infusion (p = 0.02 and 0.001, respectively), and to 128.9 ±1.7 and 13.02 ±0.5, respectively, 12-weeks after FCM infusion (p = 0.0008 and 0.02, respectively).In addition, the pre-treatment RBCs mean corpuscular volume and RBCs mean corpuscular haemoglobin (MCH) significantly increased from 72.02 ±3.5 fl and 23.9 ±1.9 pg, respectively, to 90.6 ± 2.8 fl and 29.98 ±1.5 pg, respectively, 6 weeks after FCM infusion (p = 0.01 and p = 0.007, respectively), and to 89.5 ±2.9 fl and 30.2 ±1.5 pg, respectively, 12 weeks after FCM infusion (p = 0.02 and 0.007 respectively).Conclusions: The ferric carboxy maltose was safe and effective for the treatment of ID/IDA during pregnancy within 6 weeks. The serum ferritin and Hb levels and the RBC indices remained significantly high 12 weeks after FCM infusion compared to the pre-treatment values.

A new effect of intravenous iron treatment in pregnancy: contraction in nonstress test and timing of labor

“…Pregnant women who had a singleton pregnancy between 35 and 37 weeks of gestation and received IV iron treatment due to existing anemia (despite oral iron therapy) according to WHO criteria were included in our study. Iron deficiency anemia was diagnosed when the hemoglobin was <10 g/dL and ferritin was <15 ng/mL 10 . Women who had any complications in pregnancy (preeclampsia, diabetes mellitus, IUGR, malpresentation, trauma, etc.…”

“…IV iron doses required to correct iron deficiency anemia when Hb was <10 g/dL according to body weight were 500 mg (<35 kg), 1,500 mg (>35 to<70 kg), and 2,000 mg (>70 kg). The maximum recommended iron infusion dose was 1,000 mg of iron/week (1,000 mg in the first session and the remaining amount in the second session after 1 week) 10 . Ferric carboxymaltose was administered as a single dose of 1,000 mg via IV drip infusion, to be completed in 15 min.…”

Assessing psychometric challenges and fatigue during the COVID-19 pandemic

“…The collected data were analyzed using Chi-square test (x2) and MedCalc 20.106 (MedCalc., Belgium) to identify populations vulnerable to psychometric challenges and fatigue during the Covid-19 pandemic in the Republic of Kazakhstan, with a significance level set at p<0.05. The G Power 3.1.9.7 (Düsseldorf; Germany) [23,24] was used to calculate the sample size of this study, with 0.05 probability, 0.95% power, and 0.3 sample size. The Chi-square test (x2) was used for statistical analysis.…”