Efficacy of five-flash intense pulsed light therapy technique in patients with meibomian gland dysfunction

Zarei‐Ghanavati, Siamak; Hassanzadeh, Samira; Khorasani, Abbas Azimi; Ehsaei, Asieh; Bakhtiari, Elham

doi:10.1080/08164622.2021.1976595

Cited by 14 publications

(24 citation statements)

References 37 publications

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“…The studies were excluded for the following reasons: theoretical research (15), no clinical outcomes (13), and no RCT (18). Finally, 15 RCTs 10–24 involving 1,142 patients (2,284 eyes) met the inclusion criteria and were included in this meta-analysis. The article screening process is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Miao

Yan

Jia

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Section: Resultsmentioning

confidence: 99%

Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Miao

Yan

Jia

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Furthermore, Iradier et al showed that this change in osmolarity correlated significantly with the baseline osmolarity in both eyes. [15][16][17] Multiple pretreatment factors have been shown to correlate with clinical outcomes. In the present study, increased pre-treatment OSDI, hyperemia, corneal staining, conjunctival staining and Schirmer test were significantly associated with an improvement in symptoms (OSDI).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Iradier et al showed that this change in osmolarity correlated significantly with the baseline osmolarity in both eyes. 15–17…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of intense pulsed light of upper and lower eyelids in Meibomian gland dysfunction: A prospective multicentric study

Benitez-del-Castillo,

López-Pérez,

Cano-Ortiz

et al. 2023

European Journal of Ophthalmology

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Purpose To demonstrate that intense pulsed light therapy (IPL) of the upper and lower eyelids with meibomian gland expression (MGX) is effective in improving dry eye disease due to meibomian gland dysfunction (MGD). Methods Patients with ocular discomfort (Ocular Surface Disease Index -OSDI- above 13) and signs of MGD were recruited. All patients underwent OSDI, visual acuity (VA), intraocular pressure, Schirmer test, meibography, non-invasive tear breakup time (NITBUT), slit-lamp examination (corneal and conjunctival staining, hyperemia, gland expressibility, and meibum quality), tear osmolarity and lipid layer thickness. IPL was performed with Optima IPL (Lumenis Ltd.) following a standardized protocol on upper and lower eyelids of both eyes, with inferior eyelid MGX. Patients received four sessions separated by two weeks each. Four weeks after, examinations were repeated. Results 160 patients (320 eyes) were included, of which 108 (67.5%) were women and mean age was 59.2 ± 15.08 (range 20–89). After four sessions, VA, OSDI, tear osmolarity, lipid layer thickness, NITBUT, hyperemia, corneal and conjunctival staining, gland expressibility, meibum quality, inferior eyelid Meiboscore and Schirmer test improved (all, p < 0.027). Changes in OSDI, initial and average NITBUT increased with dry eye disease severity (according to OSDI). Increased pre-treatment OSDI, hyperemia, corneal and conjunctival staining and Schirmer test were associated with an improvement in OSDI (all, p < 0.040). No adverse events were noted. Conclusions The combination of IPL on upper and lower eyelids with MGX is safe and effective for the treatment of MGD. Patients with severe dry eye disease present greater improvements.

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“…Among the studies evaluating IPL as a standalone treatment, 12 were randomised control trials (Craig et al, 2015; Gao et al, 2019; Piyacomn et al, 2019; Song et al, 2021; Wu et al, 2020; Wu, Xu, et al, 2022; Xu et al, 2022; Xue et al, 2020; Yan & Wu, 2021; Yang, Pazo, Qin, et al, 2021; Yang, Pazo, Zhang, et al, 2021; Zarei‐Ghanavati, Hassanzadeh, Azimi Khorasani, et al, 2021; Zhang et al, 2019), and five of these compared treatment efficacy to that of sham treatment (Craig et al, 2015; Piyacomn et al, 2019; Song et al, 2021; Xue et al, 2020; Yang, Pazo, Qin, et al, 2021; Yang, Pazo, Zhang, et al, 2021). In the sham‐controlled trials, all demonstrated significantly decreased symptom score and all but one found improved tear film stability in the IPL cohorts compared to controls (Xue et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future

Fineide,

Magnø,

Khan

et al. 2023

Acta Ophthalmologica

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Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. It is considered an inflammatory disease and the most common cause is meibomian gland dysfunction. Despite many treatment alternatives being available, including artificial tears, warm compresses, antibiotics, and anti‐inflammatory therapy, lasting treatment effects are rare. Over the last two decades, intense pulsed light therapy, after being well established in dermatology, has been gradually introduced to the field of ophthalmology to treat meibomian gland dysfunction. The purpose of the current article is to critically review the clinical studies assessing the use of intense pulsed light to treat meibomian gland dysfunction published to date. The vast majority of the included studies demonstrated improved symptoms and signs, although the degree of efficacy and its duration varied greatly depending on concomitant treatment, number of treatment sessions, and other factors. Several possible mechanisms of action concerning disease propagation and treatment efficacy are discussed. There is still a need for larger, randomised, longitudinal studies to define the most efficacious treatment regime and to predict which patients may benefit the most. More studies are needed on implementing biochemical analyses and machine learning algorithms. Such studies may prove beneficial in predicting treatment effects, defining optimal treatment regimens, and furthering our understanding of the mechanisms of action.

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Efficacy of five-flash intense pulsed light therapy technique in patients with meibomian gland dysfunction

Cited by 14 publications

References 37 publications

Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Efficacy and safety of intense pulsed light of upper and lower eyelids in Meibomian gland dysfunction: A prospective multicentric study

Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future

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